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Antiallergic and Anti-inflammatory Effects of Perilla frutescens var. acuta  

You, Jin-Su (College of Pharmacy, Woosuk University)
Kim, Sang-Yong (Korea National Arboretum)
Kim, Sang-Hyun (Department of Pharmacology, School of Medicine, Kyungpook National University)
Shin, Tae-Yong (College of Pharmacy, Woosuk University)
Publication Information
Korean Journal of Pharmacognosy / v.43, no.2, 2012 , pp. 163-166 More about this Journal
Abstract
In the present study, we investigated the effect of the water extract of Perilla frutescens var. acuta (Labiatae; WEPF) on the mast cell-mediated allergic reactions. WEPF was anally administered to mice for high and fast absorption. WEPF inhibited compound 48/80-induced systemic allergic reaction. WEPF attenuated immunoglobulin E (IgE)-mediated local allergic reaction. In addition, WEPF decreased the gene expression of pro-inflammatory cytokines in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated HMC-1 cells. These results indicate that WEPF inhibits mast cell-mediated allergic reactions in vivo and in vitro.
Keywords
Perilla frutescens var. acuta; Allergic inflammation; Mast cell; Tumor necrosis factor-${\alpha}$; Interleukin-6;
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