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Anti-hyperlipidemic Effect of the Isolated Component, Quercetin-3-O-rhamnoside and the Fractions from the Extract of Houttuynia Cordata in Mice  

Kim, Do-Kuk (Department of Oriental Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University)
Kim, Se-Gun (Department of Oriental Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University)
Poudel, Amrit (Department of Oriental Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University)
Jeong, Tae-Suk (Korea Research Institute of Bioscience & Biotechnology, Biosystem Research, Industrial Bio-materials Research Center)
Jung, Hyun-Ju (Department of Oriental Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University)
Publication Information
Korean Journal of Pharmacognosy / v.43, no.2, 2012 , pp. 101-106 More about this Journal
Abstract
The anti-hyperlipidemic effect of Houttuynia cordata was assessed in poloxamer-407 induced hyperlipidemic mice model. The butanol fraction and its isolated compound, quercetin-3-O-rhamnoside, significantly reduced the blood triglyceride and total-cholesterol level and increased the blood HDL-cholesterol level. They also showed the significant reductive effect on the blood AST and ALT level, rising in proportion to the liver damage, in hyperlipidemic mice.
Keywords
Houttuynia cordata; Saururaceae; Quercetin-3-O-rhamnoside; Anti-hyperlipidemic effect;
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