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Enhancement of Anti-tumor Immunity by Administration of Macrolepiota procera Extracts  

Han, Kyung-Hoon (Division of Clinical Research, Medical Institute, Seoul Medical Center)
Kim, Doh-Hee (Division of Clinical Research, Medical Institute, Seoul Medical Center)
Song, Kwan-Yong (Division of Clinical Research, Medical Institute, Seoul Medical Center)
Lee, Kye-Heui (Division of Clinical Research, Medical Institute, Seoul Medical Center)
Kang, Tae-Bong (Department of Biotechnology, Konkuk University)
Yoon, Taek-Joon (Department of Food & Nutrition, Yuhan University)
Publication Information
Korean Journal of Pharmacognosy / v.43, no.1, 2012 , pp. 32-38 More about this Journal
Abstract
To examine the potentiation of Macrolepiota procera extracts (MPE-4) to act as adjuvant enhancing the tumor specific anti-tumor immune response, tumor vaccine prepared by boiling (HK vaccine) admixed with MPE-4 and immunized in mice. Vaccination of mice with HK vaccine in combination with MPE-4 resulted in higher inhibition in tumor metastasis compared with the mice of HK vaccine alone treatment against live syngeneic tumor cell challenge. The splenocytes from mice immunized HK vaccine mixed with MPE-4 was able to elicit a stronger cytotoxic T lymphocyte (CTL) response as compared with HK vaccine alone. In addition, the splenocytes from MPE-4 admixed HK vaccine immunized mice secreted a higher concentration of Th1 type cytokine such as IFN-${\gamma}$, and GM-CSF. Furthermore, the adoptive transfer of splenocytes from mice immunized HK vaccine and MPE-4 led to a more robust anti-tumour response than the HK vaccine alone. Overall, these results indicate that MPE-4 is a good candidate adjuvant of anti-tumor immune response.
Keywords
Tumor immunity; Macrolepiota procera; Adjuvant; Cytokine; Adoptive transfer;
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1 Emens, L. A. (2006) Roadmap to a better therapeutic tumor vaccine. Int Rev Immunol. 25: 415-443.   DOI   ScienceOn
2 Burnet, F. M. (1970) The concept of immunological surveillance. Prog. Exp. Tumor Res. 13: 1-27.
3 Rosenberg, S. A., Yang, J. C. and Restifo, N. P. (2004) Cancer immunotherapy: moving beyond current vaccines. Nat. Med. 10: 909-915.   DOI   ScienceOn
4 Gough, M. J., Melcher, A. A., Ahmed, A., Crittenden, M. R., Riddle, D. S., Linardakis, E., Ruchatz, A. N., Emiliusen, L. M. and Vile, R. G. (2001) Macrophages orchestrate the immune response to tumor cell death. Cancer Res. 61(19): 7240-7247.
5 Schnurr, M., Scholz, C., Rothenfusser, S., Galambos, P., Dauer, M., Robe, J., Endres, S. and Eigler, A. (2002) Apoptotic pancreatic tumor cells are superior to cell lysates in promoting cross-priming of cytotoxic T cells and activate NK and gammadelta T cells. Cancer Res. 62: 2347-2352.
6 Strome, S. E., Voss, S., Wilcox, R., Wakefield, T. L., Tamada, K., Flies, D., Chapoval, A., Lu, J., Kasperbauer, J. L., Padley, D., Vile, R., Gastineau, D., Wettstein, P. and Chen, L. (2002) Strategies for antigen loading of dendritic cells to enhance the antitumor immune response. Cancer Res. 62: 1884-1889.
7 Wolfers, J., Lozier, A., Raposo, G., Regnault, A., Thery, C., Masurier, C., Flament, C., Pouzieux, S., Faure, F., Tursz, T., Angevin, E., Amigorena, S. and Zitvogel, L. (2001) Tumorderived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat. Med. 7: 297-303.   DOI   ScienceOn
8 Ahmad, M., Rees, R. C. and Ali, S. A. (2004) Escape from immunotherapy: possible mechanisms that influence tumor regression/progression. Cancer Immunol. Immunother. 53: 844-854.
9 Ha, E. S., Hwang, S. H., Shin, K. S., Yu, K. W., Lee, K. H., Choi, J. S., Park, W. M. and Yoon T. J. (2004) Anti-metastatic activity of glycoprotein fractionated from Acanthopanax senticosus, involvement of NK-cell and macrophage activation. Arch. Pharm. Res. 27: 217-224.   DOI   ScienceOn
10 Zhang, S., Li, W., Xia, Z. and Mao, Y. (2011) CD4 T cell dependent tumor immunity stimulated by dendritic cell based vaccine. Biochem. Biophys. Res. Commun. 413: 294-298.   DOI   ScienceOn
11 Fields, R. C., Shimizu, K. and Mule, J. J. (1998) Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responses in vitro and in vivo. Proc. Natl. Acad. Sci. USA 95: 9482-9487.   DOI   ScienceOn
12 Nouri-Shirazi, M., Banchereau, J., Bell, D., Burkeholder, S., Kraus, E. T , Davoust, J. and Palucka, K. A. (2000) Dendritic cells capture killed tumor cells and present their antigens to elicit tumor-specific immune responses. J. Immunol. 165: 3797-803.
13 Pandolfi, F., Cianci, R., Lolli, S. and Dunn, I.S., Newton, E. E., Haggerty, T.J., Boyl,e L.A. and Kurnick, J. T. (2008) Strategies to overcome obstacles to successful immunotherapy of melanoma. Int. J. Immunopathol. Pharmacol. 21: 493-500
14 Song, S., Zhang, K., You, H., Wang, J., Wang, Z., Yan, C. and Liu, F. (2010) Significant anti-tumour activity of adoptively transferred T cells elicited by intratumoral dendritic cell vaccine injection through enhancing the ratio of CD8(+) T cell/ regulatory T cells in tumour. Clin. Exp. Immunol. 162: 75-83.   DOI   ScienceOn
15 Ogino, T., Bandoh, N., Hayashi, T., Miyokawa, N., Harabuchi, Y. and Ferrone, S. (2003) Association of tapasin and HLA class I antigen down-regulation in primary maxillary sinus squamous cell carcinoma lesions with reduced survival of patients. Clin. Cancer Res. 9: 4043-4051.
16 Prasad, S. J., Farrand, K. J., Matthews, S. A., Chang, J. H., McHugh, R. S. and Ronchese, F. (2005) Dendritic cells loaded with stressed tumor cells elicit long-lasting protective tumor immunity in mice depleted of $CD4^{+}CD25^{+}$ regulatory T cells. J. Immunol. 174: 90-98.
17 Witham, T. F., Villa, L., Yang, T., Pollack, I. F., Okada, H., Robbins, P. D. and Chambers, W. H. (2003) Expression of a soluble transforming growth factor-beta (TGFbeta) receptor reduces tumorigenicity by regulating natural killer (NK) cell activity against 9L gliosarcoma in vivo. J. Neurooncol. 64: 63-69.
18 Cheuk, A. T., Chan, L., Czepulkowski, B., Berger, S. A., Yagita, H., Okumura, K., Farzaneh, F., Mufti, G. J. and Guinn, B. A. (2006) Development of a whole cell vaccine for acute myeloid leukaemia. Cancer Immunol. Immunother. 55: 68-75.   DOI   ScienceOn
19 Copier, J. and Dalgleish, A. (2006) Overview of tumor cellbased vaccines. Int. Rev. Immunol. 25: 297-319.   DOI   ScienceOn
20 Korbelik, M. and Sun, J. (2006) Photodynamic therapy-generated vaccine for cancer therapy. Cancer Immunol. Immunother. 55: 900-909.   DOI   ScienceOn
21 Yoon, T. J., Kim, J. Y., Kim, H., Hong, C., Lee, H., Lee, C. K., Lee, K. H., Hong, S. and Park, S. H. (2008) Anti-tumor immunostimulatory effect of heat-killed tumor cells. Exp. Mol. Med. 40: 130-144.   DOI   ScienceOn
22 Berzofsky, J. A., Terabe, M., Oh, S., Belyakov, I. M., Ahlers, J. D., Janik, J. E. and Morris, J. C. (2004) Progress on new vaccine strategies for the immunotherapy and prevention of cancer. J. Clin. Invest. 113: 1515-1525.
23 Miconnet, I., Koenig, S., Speiser, D., Krieg, A., Guillaume, P., Cerottini, J. C. and Romero, P. (2002) CpG are efficient adjuvants for specific CTL induction against tumor antigenderived peptide. J. Immunol. 168: 1212-1218.
24 Seliger, B. (2005) Strategies of tumor immune evasion. Bio- Drugs 19: 347-354.
25 Kim, H. J. and Lee, I. S. (2004) Antimutagenic and cytotoxic effects of Korean wild mushrooms extracts. Korean J. Food Sci. Technol. 36: 662-668.
26 Barros, L., Baptista, P., Correia, D. M., Morais, J. S. and Ferreira, I. C. (2007) Effects of conservation treatment and cooking on the chemical composition and antioxidant activity of Portuguese wild edible mushrooms. J. Agric. Food Chem. 55: 4781-4788.   DOI   ScienceOn
27 Han, K.H., Kim, D. H., Song, K. Y., Jo, S. Y., Lee, S.W. and Yoon, T. J. (2010) Activation of innate immunity by Lepiota procera enhances antitumor activity. Kor. J. Pharmacogn. 41: 115-121.
28 Gutzmer, R., Li, W., Sutterwala, S., Lemos, M. P., Elizalde, J. I., Urtishak, S. L., Behrens, E. M., Rivers, P. M., Schlienger, K., Laufer, T. M., Eck, S. L. and Marks, M. S. (2004) A tumor-associated glycoprotein that blocks MHC class IIdependent antigen presentation by dendritic cells. J. Immunol. 173: 1023-3102.