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Inhibitory Effects of Triticum aestivum L. Extracts on Liver Lipid Accumulation in High Fat-Fed Mice  

Lee, Sun-Hee (Department of Immunology and Institute of Medical Science, Chonbuk National University Medical School)
Lim, Sung-Won (Department of Immunology and Institute of Medical Science, Chonbuk National University Medical School)
Lee, Young-Mi (Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University)
Seo, Joo-Won (Division of Bioscience and Bioinformatics, College of Natural Science and Research Center for Bio Food and Drug Materials, Myongji University)
Kim, Dae-Ki (Department of Immunology and Institute of Medical Science, Chonbuk National University Medical School)
Publication Information
Korean Journal of Pharmacognosy / v.42, no.4, 2011 , pp. 309-316 More about this Journal
Abstract
Fatty liver disease refers to a range of disorders associated with fatty liver, which occur in excessive eating, evident infection or significant consumption of alcohol. This study was to investigate the effects of water and ethanol extracts of Triticum aestivum young leaf on lipid metabolism and accumulation in liver of mice fed with high-fat diet. Male C57BL/6 mice were divided into normal diet group, high fat diet (HFD) group, high fat diet group administrated with 200 mg/kg/day of T. aestivum water extract (HFD-TAWE) and high-fat group administrated with 200 mg/kg/day of T. aestivum ethanol extract (HFD-TAEE). TAWE and TAEE were administrated orally for 5 weeks once at the same time point. Both TAWE and TAEE significantly reduced body weight, food intake and liver tissue weight, which were augmented in high fat-fed mice. The serum levels of triglyceride, total and LDL-cholesterol also were significantly attenuated in both HFD-TAWE and HFD-TAEE groups compared to the HFD group. Moreover, administration of HFD-TAWE or HFD-TAEE reduced the lipid accumulation in liver tissue of mice fed with high fat diet. Levels of total lipids and triglyceride in liver tissues also was significantly reduced in HFDTAWE and HFD-TAEE groups compared to HFD group. The activities of serum ALT and AST revealed in HFD group were remarkedly decreased in HFD-TAEE groups. These results indicate that both water and ethanol extract of T. aestivum may improve the lipid accumulation in liver as well as lipid metabolism in serum, and that in particular, the ethanol extract of T. aestivum may has the potent anti-hyperlipidemic effect, suggesting that it may be a useful candidate for the therapy preventing fatty liver diseases.
Keywords
Triticum aestivum. hepatostaetosis; cholesterol; triglyceride; high-fat diet;
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