Browse > Article

Tyrosinase, Hyaluronidase Inhibitory Effect and Antioxidant Activity of Medicinal Plants  

Cha, Bae-Cheon (Department of Pharmaceutical Engineering, College of Health Sciences, Sangji University)
Publication Information
Korean Journal of Pharmacognosy / v.42, no.1, 2011 , pp. 89-97 More about this Journal
Abstract
This study was conducted to investigate tyrosinase inhibitory effect, hyaluronidase inhibitory effect and antioxidant activity by DPPH radical scavenging method on the MeOH extract of 50 species medicinal plant for screening of functional properties. As a result, Chaenomeles sinensis Koehne extract among 50 species medicinal plant turned out to be having tyrosinase, hyaluronidase inhibitory effect and antioxidant activity. The major component of tyrosinase and hyaluronidase inhibitory effect was isolated from EtOAc extract of Chaenomeles sinensis Koehne. And the component of antioxidant activity was isolated from n-BuOH extract of Chaenomeles sinensis Koehne. Their structure of compounds were identified as oleanolic acid and (-)-epicatechin by spectroscopic evidence, respectively.
Keywords
Tyrosinase inhibitory effect; Hyaluronidase inhibitory effect; Antioxidant activity; Medicinal plant; Chaenomeles sinensis Koehne; Oleanolic acid; (-)-Epicatechin;
Citations & Related Records
Times Cited By KSCI : 12  (Citation Analysis)
Times Cited By SCOPUS : 2
연도 인용수 순위
1 Hanninen, O., Kaartinen, K., Rauma, A. L., Nenonen, M., Torronen, R., Hakkinen, S., Adlercreutz, H. and Laakso, J. (2000) Antioxidants in vegan diet and rheumatic disorders. Toxicology 155: 45-53.   DOI
2 Jeong, H. S., Han, J. G., Ha, J. H., Kim, Y., Oh, S. H., Kim, S. S., Jeong, M. H., Choi, G. P, Park, U. Y. and Lee, H. Y. (2009) Antioxidant activities and skin-whitening effect of nano-encapsuled water extract from Rubus coreanus Miquel. Korean J. Medicinal Crop Sci. 17: 83-89.
3 Chan, E. W. C., Lim, Y. Y., Wong, L. F., Lianto, F. S., Wong, S. K., Lim, K. K., Joe, C. E. and Lim, T. Y. (2008) Antioxidant and tyrosinase inhibition properties of leaves and rhizomes of ginger species. Food Chem. 109: 477-483.   DOI   ScienceOn
4 Karioti, A., Protopappa, A., Megoulas, N. and Skaltsa, H. (2007) Identification of tyrosinase inhibitors from Marrubium velutium and Marrubium cylleneum. Bioorg. Med. Chem. 15: 2708-2714.   DOI   ScienceOn
5 Likhitwitayawuid, K., Sornsute, A., Sritularak, B. and Ploypradith, P. (2006) Chemical transformations of oxyresveratrol (trans-2,4,3',5'-tetra hydroxystilbene) into a potent tyrosinase inhibitor and strong cytotoxic agent. Bioorg. Med. Chem. Lett. 16: 5650-5653.   DOI   ScienceOn
6 Natsume, M., Osakabe, N., Oyama, M., Sasaki, M., Baba, S., Nakamura, Y., Osawa, T. and Terao, J. (2003) Structure of (-)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (-)-epicatechin : differences between human and rat. Free Radical Biol. Med. 34: 840-849.   DOI   ScienceOn
7 Berregi, I., Santos, J. I., Campo, G. and Miranda, J. I. (2003) Quantitative determination of (-)-epicatechin in cider apple juices by $^1H$ NMR. Talanta, 61: 139-145.   DOI   ScienceOn
8 Cren-Olive, C., Wieruszeski, J. M., Maes, E. and Rolando, C. (2002) Catechin and epicatechin deprotonation followed by $^{13}C$ NMR. Tetrahedron Lett. 43: 4545-4549.   DOI   ScienceOn
9 Cha, B. C., Lee, E. H. and Noh, M. A. (2005) Antioxidant activity of Spatholobus suberectus Dunn. Kor. J. Pharmacogn. 36: 50-55.
10 Maeda, K. and Fukuda, M. (1991) In vitro effectiveness of several whitening cosmetic components in human melanocytes. J. Soc. Cosmet. Chem. 42: 361-368.
11 Jeong, S. I., Cho, J. K., Mok, J. Y., Kim, S. J., Park, J. M., Jeon, I. H., Kim, H. S. and Jang, S. I. (2010) Antioxidant activity of Persimmon leaves during growth. Kor. J. Pharmacogn. 41: 255-263.
12 Koo, U., Lee, H. J., Lee, D. H., Lee, H. J., Ham, A. R., Cho, E. Y. and Mar, W. C. (2008) Anti-oxidative effect of some plant extracts against nitric oxide-induced oxidative stress on neuronal cell. Kor. J. Pharmacogn. 39: 290-294.
13 Miliauskas, G., Venskutonis, P. R. and Van-Beek, T. A. (2004) Screening of radical scavenging activity of some medicinal and aromatic plant extracts. Food Chem. 85: 231-237.   DOI   ScienceOn
14 Han, W. and Wang, M. H. (2010) Radical scavenging and anti- inflammation activities from different extracts of Zanthoxylum schnifolium fruits. Kor. J. Pharmacogn. 41: 250-254.
15 Jeong, S. J., Ko, Y. S., Ahn, N. H. and Kim, Y. C. (1998) Hyaluronidase inhibitor from Uncariae ramulus et Uncus. Kor. J. Pharmacogn. 29: 169-172.
16 Kim, Y. S., Noh, Y. K., Lee, G. I., Kim, Y. K., Lee, K. S. and Min, K. R. (1995) Inhibitory effects of herbal medicines on hyaluronidase activity. Kor. J. Pharmacogn. 26: 265-272.
17 Cha, B. C. and Lee, E. H. (2004) Antioxidant and antiinflammation activities of Prunus persica tree extracts. Korean J. Medicinal Crop Sci. 12: 289-294.
18 Kim, J. S., Kim, Y. J., Lee, S. Y. and Kang, S. S. (2008) Phytochemical studies on Paeoniae radix (3)-Triterpenoids. Kor. J. Pharmacogn. 39: 37-42.
19 Park, J. C., Lee, J. I. and Ahn, S. D. (1989) Study on the constituents in the fruit of Chaenomeles sinensis Koehne. Kor. J. Pharmacogn. 20: 10-12.
20 Bae, J. H., Lee, W. W., Suh, K. S. and Kim, S. T. (2000) The effect of oleanolic acid and ursodeoxycholic acid on the pigmentation in the mouse by ultraviolet-B(UVB) irradiation. Korean J. Innvestigative dermatology 7: 223-229.
21 Marquina, M. A., Corao, G. M., Araujo, L., Buitrago, D. and Sosa, M. (2002) Hyaluronidase inhibitory activity from the polyphenols in the fruit of blackberry (Rubus fruticosus B.). Fitoterapia 73: 727-729.   DOI   ScienceOn
22 Ghosh, P. (1994) The role of hyaluronic acid(hyaluronan) in health and disease: interactions with cells, cartilage and components of synovial fluids. Clin. Exp. Rheumatol. 12: 75-82.
23 Yang, S. W., Park, S. R., Ahn, D. R., Yang, J. H., Cho, C. H., Hwang, Y. H., Park, J. H. and Kim, D. K. (2010) DPPH free radical scavenging effect of the aerial parts of Desmodium oldhami. Kor. J. Pharmacogn. 41: 180-184.
24 Choi, S. S., Yim, D. S. and Lee, S. Y. (2009) Radical scavenging activities and protective effects against oxidative damage to DNA of extracts from medicinal plants with known osteoprotective effects. Kor. J. Pharmacogn. 40: 143-149.
25 Uchiyama, M., Suzuki, Y. and Fukuzawa, K. (1968) Biochemical studies of physiological function of tocopheronolactone. 1. Yakugaku Zasshi 88: 678-683.
26 Hearing, J. R. and Hearing, V. J. (1987) Mammalian monophenol monooxygenase(Tyrosinase) : Purification, properties and reaction catalyzed. Method on Enzymology 142: 154-165.
27 Lee, Y. M., Shin, H. D., Lee, J. J. and Lee, M. Y. (2007) Antioxidative effect of Chaenomelis Fructus ethanol extract. Korean J. Food Preserv. 14: 177-182.
28 Liu, J. (1995) Pharmacology of oleanolic acid and ursolic acid. J. Ethnopharmacol. 49: 57-68.   DOI   ScienceOn
29 Lee, C. B. (1982) Forest Economics-mokchogangmok. Korean plant map. 29, Hyangmunsa, Seoul, Korea.
30 Lee, D. H., Kim, J. H., Kim, N. M., Choi, J. S. and Lee, J. S. (2002) Physiological functionality of chinese quince wine and liquors. Kor. J. Biotechnol. Bioeng. 17: 266-270.
31 Baek, M. Y., Cho, J. G., Lee, D. Y., Ahn, E. M., Jeong, T. S. and Baek, N. I. (2010) Isolation of triterpenoids from the stem bark of Albizia julibrissin and their inhibition activity on ACAT-1 and ACAT-2. J. Korean Soc. Appl. Biol. Chem. 53: 310-315.   DOI
32 Masaki, H. (2010) Role of antioxidants in the skin: Antiaging effects. J. Dermatol. Sci. 58: 85-90.   DOI   ScienceOn
33 Lee, N. H., Lee, S. J., Jung, D. S., Bu, H. J., Yang, H. C. and Riu, K. Z. (2001) Screening of the tyrosinase inhibition and hyaluronidase inhibition activities, and radical scavenging effects using plants in Cheju. Kor. J. Pharmacogn. 32: 175-180.
34 Yoshikawa, M., Harada, E., Miki, A., Tsukamoto, K., Liang, S. Q., Yamahara, J. and Murakami, N. (1994) Antioxidant constituents from the fruit hulls of Mangosteen(Garcinia mangostana L.) originating in Vetnam. Yakugaku Zasshi 114: 129-133.
35 Park, S. R., Yang, S. W., Ahn, D. R., Yang, J. H., Cho, C. H., Kim, H. Y., Lee, J. H., Park, J. S. and Kim, D. K. (2010) Antioxidant Constituents of the heartwood of Cedrela sinsesis A. Juss. Kor. J. Pharmacogn. 41: 245-249.
36 Meyer, K. (1947) The biological significance of hyaluronic acid and hyaluronidase. Physiol. Rev. 27: 335-359.
37 Halliwell, B. (1991) Drug antioxidant effects. Drugs 42: 569-605.   DOI   ScienceOn
38 Korner, A. and Pawelek, J. (1982) Mammalian tyrosinase catalases three reactions in the biosynthesis of melanin. Science 217: 1163-1165.   DOI