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Screening of Chinese Herbal Medicines with Inhibitory Effect on Aldose Reductase (IV)  

Lee, Yun-Mi (Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine)
Kim, Young-Sook (Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine)
Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
Kim, Joo-Hwan (Department of Life Science, Kyungwon University)
Kim, Jin-Sook (Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine)
Publication Information
Korean Journal of Pharmacognosy / v.41, no.4, 2010 , pp. 289-296 More about this Journal
Abstract
Aldose reductase (AR), the principal enzyme of the polyol pathway, has been shown to play an important role in the development of the diabetic complications. Evaluating natural sources for ARI potential may lead to the development of safer and more effective agents against diabetic complications. Sixty four Chinese herbal medicines have been investigated for inhibitory activities on AR. Among them, thirteen herbal medicines, Inula helianthus-aquatilis C. Y. Wu ex Ling. (whole plant), Erigeron breviscapus (Vant.) Hand. Mazz. (whole plant), Lonicera hypoglauca Miq. (leaf, stem), Scutellaria orthocalyx Hang. Mazz. (whole plant), Berchemia floribunda Brongn. (leaf, stem), Michelia alba DC. (flower), Oroxylum indicum (seed), Punica granatum L. (peel), Elsholtzia capituligera (whole plant), Trachelospermum jasminoides (Lindl.) Lem. (whole plant), Elsholtzia strobilifera Benth. (whole plant), Agrimonia pilosa var. nepalensis (D. Don) Nakai (whole plant) and Aster poliothamnus Diels (whole plant) exhibited a significant inhibitory activity against AR. Particularly, Inula helianthus-aquatilis C. Y. Wu ex Ling. showed seven times more potent inhibitory activity than the positive control, 3,3-tetramethyleneglutaric acid (TMG).
Keywords
diabetic complications; aldose reductase inhibitor; Chinese herbal medicines;
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1 Yoo, N. H., Jang, D. S., Lee, Y. M., Jeong, I. H., Cho, J. H., Kim, J. H. and Kim, J. S. (2010) Anthraquinones from the roots of Knoxia valerianoides inhibit the formation of advanced glycation end products and rat lens aldose reductase in vitro. Arch. Pharm. Res. 33: 209-214.   DOI   ScienceOn
2 Jang, D. S., Yoo, N. H., Kim, N. H., Lee, Y. M., Kim, C. S., Kim, J. Kim, J. H. and Kim, J. S. (2010) 3,5-Di-O-caffeoylepi-quinic acid from the leaves and stems of Erigeron annuus inhibits protein glycation, aldose reductase and cataractogenesis. Biol. Pharm. Bull. 33: 329-333.   DOI   ScienceOn
3 Zhang, J., Chen, Y., Li, B. and Wang, M. (1997) Chemical constituents of Aster poliothamnus Diels. Zhongguo Zhong Yao Za Zhi 22: 103-104, 128.
4 Wang, H. M., Lo, W. L., Huag, L. Y., Wang, Y. D. and Chen, C. Y. (2010) Chemical constituents from the leaves of Michelia alba. Nat. Prod. Res. 24: 398-406.   DOI   ScienceOn
5 Tao, Y. H., Jiang, D. Y., Xu, H. B. and Yang, X. L. (2008) Inhibitory effect of Erigeron breviscapus extract and its flavonoid components on GABA shunt enzymes. Phytomedicine 15: 92-97.   DOI   ScienceOn
6 Sudheesh, S. and Vijayalakshmi, N. R. (2005) Flavonoids from Punica granatum potential antiperoxidative agents. Fitoterapia 76: 181-186.   DOI   ScienceOn
7 Chen, L. J., Games, D. E. and Jones, J. (2003) Isolation and identification of four flavonoid constituents from the seeds of Oroxylum indicum by high-speed counter-current chromatography. J. Chromatogr. A. 988: 95-105.   DOI   ScienceOn
8 Jung, C. H., Jung. S., Ding, G. X., Kim, J. H., Hong, M. H., Shin, Y. C., Kim, G. and Ko, S. G. (2006) Antihyperglycemic activity of herb extracts on streptozotocin-induced diabetic rats. Biosci. Biotechnol. Biochem. 70: 2556-2559.   DOI   ScienceOn
9 Singh, R. P., Chidambara Murthy, K. N. and Jayaprakasha, G. K. (2002) Studies on the antioxidant activity of Pomegranate (Punica granatum) peel and seed extracts using in vitro models. J. Agric. Food Chem. 50: 81-86.   DOI   ScienceOn
10 Song, B. H., Tran, H. N. A. and Bae, S. Y. (2007) Pomegranate (Punica granatum) as resources of phytoestrogen and anticancer substances. Kor. J. Microbiol. Biotechnol. 35: 81-97.   과학기술학회마을
11 Xin-Hua-Ben-Cao-Guang-YaoN. (1990) Jiangsu New Medical College, Shanghai Technology Publisher Shanghai, 156.
12 Wei, X., Jiang, J. S., Feng, Z. M and Zhang, P. C. (2008) Anthraquinone-benzisochromanquinone dimers from the roots of Berchemia floribunda. Chem. Pharm. Bull. 56: 1248-1252.   DOI   ScienceOn
13 Wang, Y. F., Cao, J. X., Efferth, T., Lai, G. F. and Luo, S. D. (2006) Cytotoxic and new tetralone derivatives from Berchemia floribunda (Wall.) Brongn. Chem. Biodivers. 3: 646-653.   DOI   ScienceOn
14 Dufrane, S. P., Malaisse, W. J. and Sener, A. (1984) A micromethod for the assay of aldose reductase, its application to pancreatic islets. Biochem. Med. 32: 99-105.   DOI   ScienceOn
15 Lee, Y. M., Kim, N. H., Kim, J. M., Kim, Y. S., Jang, D. S., Kim, J. H., Bae, K. H. and Kim, J. S. (2008) Screening of inhibitory effect on aldose reductase of Korean herbal medicines and preventive effect of Catalpa bignonioides against xylose-induced lens opacity (). Kor. J. Pharmacogn. 39: 165-173.   과학기술학회마을
16 Lee, Y. M., Kim, J. M., Kim, Y. S., Jang, D. S., Kim, J. H., Bae, K. H. and Kim, J. S. (2008) Screening of inhibitory effect on aldose reductase of Vietnam herbal medicines (II). Kor. J. Pharmacogn. 39: 324-329.   과학기술학회마을
17 Lee, Y. M., Kim, J. M., Kim, Y. S., Jang, D. S., Kim, J. H., Bae, K. H. and Kim, J. S. (2009) Screening of Chinese Herbal Medicines with Inhibitory Effect on Aldose Reductase (III). Kor. J. Pharmacogn. 40: 394-399.   과학기술학회마을
18 Vinson, J. A. and Howard , T. B. (1996) Inhibition of protein glycation and advanced glycation end products by ascorbic acid and other vitamins and nutrients. J. Nutr. Biochem. 7: 659-663.   DOI   ScienceOn
19 Collins, J. B. and Corder, C. N. (1977) Aldose reductase and sorbitol dehydrogenase distribution in substrctures of normal and diabetic rats lens. Invest. Ophthamol. Visual Sci. 16: 242-243.
20 Dvonik, D., Gabbay, K. H. and Kinoshita, J. H. (1973) Polyol accumulation in galactosemic and diabetic rats. Science 182: 1146-1148.   DOI   ScienceOn
21 Jesus Angel, de la F. and Sonia, M. (2003) Aldose reductase inhibitors from natural sources. Nat. Prod. Rep. 20: 243-251.   DOI   ScienceOn
22 Chien, S. C., Yang, C. W., Tseng, Y. H., Tsay, H. S., Kuo, Y. H. and Wang, S. Y (2009) Lonicera hypoglauca inhibits xanthine oxidase and reduces serum uric acid in mice. Planta Med. 75: 302-306.   DOI   ScienceOn
23 Shan, V. O., Dorin, R. I., Sun, Y., Braun, M. and Zager, P. G. (1997) Aldose reductase gene expression is increased in diabetic nephropathy. J. Clin. Endocrinol. Metab. 82: 2294-2298.   DOI   ScienceOn
24 Tan, X. Q., Guo, L. J., Chen, H. S., Wu, L. S. and Kong, F. F. (2010) Study on the flavonoids constituents of Trachelospermum jasminoides. Zhong Yao Cai 33: 58-60.
25 Pan, Y., Liu, H. X., Zhuang, Y. L., Ding, L. Q., Chen, L. X. and Qiu, F. (2008) Studies on isolation and identification of flavonoids in herbs of Agrimonia pilosa. Zhongguo zhongyao zazhi 33: 2925-2928.
26 Melkani, A. B., Dev, V., Beauchamp, P. S., Negi, A., Mehta, S. P. S. and Melkani, K. B. (2005) Constituents of the essential oil of a new chemotype of Elsholtzia strobilifera Benth. Biochem. Syst. Ecol. 33: 419-425.   DOI   ScienceOn
27 Sheu, M. J., Chou, P. Y., Cheng, H. C., Wu, C. H., Huang, G. K., Wang, B. S., Chen, J. S., Chien, Y. C. and Huang, M. H. (2009) Analgesic and anti-inflammatory activities of a water extract of Trachelospermum jasminoides (Apocynaceae). J. Ethnopharmacol. 126: 332-338.   DOI   ScienceOn
28 Koshiura, R., Miyamoto, K., Ikeya, Y. and Taguchi., H. (1985) Antitumor activity of methanol extract from roots of Agrimonia pilosa Ledeb. Jpn. J. Pharmacol. 38: 9-16.   DOI
29 Zhu, L., Tan, J., Wang, B., He, R., Liu, Y. and Zheng, C. (2009) Antioxidant activities of aqueous extract from Agrimonia pilosa Ledeb and its fractions. Chem. Biodivers. 6: 1716-1726.   DOI   ScienceOn
30 Althunibat, O. Y., Al-Mustafa, A. H., Tarawneh, K., Khleifat, K. M., Ridzwan, B. H. and Qaralleh, H. N. (2010) Protective role of Punica granatum L. peel extract against oxidative damage in experimental diabetic rats. Process Biochem. 45: 581-585.   DOI   ScienceOn
31 Kim, C. S., Kim, J., Jeong, I. H., Kim, Y. S., Lee, J., Jang, D. S. and Kim, J. S. (2009) Slow development of diabetic cataract in streptozotocin-induced diabetic rats via inhibition of aldose reductase activity and sorbitol accumulation by use of Aster koraiensis extract. Kor. J. Pharmacogn. 40: 339-344.   과학기술학회마을
32 Bradford, M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254.   DOI   ScienceOn
33 Kinoshita, J. H., Dvornik, D., Kraml, M. and Gabbay, K. H. (1968) The effect of an aldose reductase inhibitor on the galactose-exposed rabbit lens. Biochim. Biophys. Acta. 24: 472-475.
34 Shi, J., Jiag, Y. and Liu, X. (2004) Neuroprotective effect of Erigeron breviscapus (vant) hand-mazz on NMDA-induced retinal neuron injury in the rats. Yan Ke Xue Bao. 20: 113-117.
35 Yoo, N. H., Jang, D. S., Yoo, J. L., Lee, Y. M., Kim. Y. S., Cho, J. H. and Kim, J. S. (2008) Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity. J. Nat. Prod. 71: 713-715.   DOI   ScienceOn
36 Kim, J. M., Jang, D. S., Lee, Y. M., Yoo, J. L., Kim. Y. S., Kim, J. H and Kim, J. S. (2008) Aldose reductase and protein glycation inhibitory principles from the whole plant of Duchesnea chrysantha. Chem. Biodivers. 5: 352-356.   DOI   ScienceOn
37 Fatmawati, S., Kurashiki, K., Takeno, S., Kim, Y. U., Shimizu, K., Sato, M., Imaizumi, K., Takahashi, K., Kamiya, S., Kaneko, S. and Kondo, R. (2009) The inhibitory effect on aldose reductase by an extract of Ganoderma lucidum. Phytother. Res. 23: 28-32.   DOI   ScienceOn
38 Kawanishi, K., Ueda, H. and Moriyasu, M. (2003) Aldose Reductase Inhibitors from the Nature. Curr. Med. Chem. 10: 1353-1374.   DOI   ScienceOn
39 Lee, Y. S., Kim, S. H., Jung, S. H., Kim, J. K., Pan, C. H. and Lim, S. S. (2010) Aldose reductase inhibitory compounds from Glycyrrhiza uralensis. Biol. Pharm. Bull. 33: 917-921.   DOI   ScienceOn