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The Comparison of Constituents Distributed in the Root of Angelica dahurica  

Youn, Ui-Joung (College of Pharmacy, Chungnam National University)
Yoo, Jae-Kuk (Han Kook Shin Yak)
Chen, Quan-Cheng (College of Pharmacy, Chungnam National University)
Lee, Ik-Soo (College of Pharmacy, Chungnam National University)
Na, Min-Kyun (College of Pharmacy, Yeungnam University)
Min, Byung-Sun (College of Pharmacy, Catholic University of Daegu)
Jung, Hyun-Ju (Department of Oriental Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University)
Seo, Eun-Kyoung (The Center for Cell Signaling & Drug Discovery Research, College of Pharmacy, Ewha Womans University)
Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
Publication Information
Korean Journal of Pharmacognosy / v.41, no.3, 2010 , pp. 185-189 More about this Journal
Abstract
In this study, we analyzed and quantified the amounts of bioactive phenolic constituents, xanthotoxin (1), oxypeucedanin (2), and imperatorin (3) in each part of the root of Angelica dahurica by HPLC, which validated by ICH guide lines comparing the linearity, intra day precision, inter-day precision. As a result, the amount of imperatorin 2.96% in the rootlet was two fold higher than that of the main root 1.32%. On the other hand, the amounts of xanthotoxin and oxypeucedanin in the rootlet showed similar to those of main root. In addition, the cortex of root is more plentiful of three consitituents (0.66%, 0.53%, and 1.85%) than those of xylem (0.29%, 0.05%, and 0.07%). These results show that the rootlet and cortex contain a large amount of bioactive phenolic constituent including xanthotoxin, oxypeucedanin, and imperatorin than other parts of the root.
Keywords
Angelica dahurica; xanthotoxin; oxypeucedanin; imperatorin; HPLC;
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