Browse > Article

Inhibition of IL-6 Production in TNF-$\alpha$ Stimulated MG-63 by the Triterpenoids Isolated from Aucuba japonica  

Jin, Qinglong (College of Pharmacy, Chosun University)
Jin, Hong-Guang (College of Pharmacy, Chosun University)
Shin, Ji-Eun (College of Pharmacy, Chosun University)
Choi, Eun-Jin (College of Pharmacy, Chosun University)
Woo, Eun-Rhan (College of Pharmacy, Chosun University)
Publication Information
Korean Journal of Pharmacognosy / v.41, no.2, 2010 , pp. 97-102 More about this Journal
Abstract
Six triterpenoid compounds, friedelin (1), $3{\alpha}$-hydroxy-2-friedelanone (2), canophyllol (3), oleanolic aldehyde acetate (4), ursolic acid (5), and pachysandiol A (6) were isolated from the methylene chloride soluble fraction of the roots of A. japonica. The chemical structures of compounds 1-6 were determined by the basis of physico-chemical properties and spectroscopic methods such as 1D and 2D NMR. These compounds were isolated from this plant for the first time. For the isolated compounds (1-3), the inhibitory effect of IL-6 production in TNF-$\alpha$ stimulated MG-63 was examined. Among the isolates, $3{\alpha}$-hydroxy-2-friedelanone (2) showed potent inhibitory effect on IL-6 production in TNF-$3{\alpha}$ stimulated MG-63.
Keywords
Aucuba japonica; Cornaceae; Triterpenoid; IL-6 inhibitory effect;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By SCOPUS : 0
연도 인용수 순위
1 Kim, M. R., Lee, H. H., Hahm, K. S., Moon, Y. H. and Woo, E. R. (2004) Pentacyclic triterpenoids and their cytotoxicity from the Stem Bark of Styrax japonica S. et Z. Arch. Pharm. Res. 27: 283.   과학기술학회마을   DOI   ScienceOn
2 Ibrahim, A., Khalifa, S. I., Khafagi, I., Youssef, D. T., Khan, S., Mesbah, M. and Khan, I. (2008) Microbial Metabolism of Biologically Active Secondary Metabolites from Nerium oleander L. Chem. Pharm. Bull. 56: 1253.   DOI   ScienceOn
3 Joo, S. S., Kang, H. C., Lee, M. W., Choi, Y. W. and Lee, D. I. (2003) Inhibition of IL-1beta and IL-6 in osteoblast-like cell by isoflavones extracted from Sophorae fructus. Arch Pham Res. 26: 1029.   과학기술학회마을   DOI   ScienceOn
4 Li, L., Huang, X., Sattler, I., Fu, H., Grabley, S. and Lin, W. (2006) Structure elucidation of a new friedelane triterpene from the mangrove plant Hibiscus tiliaceus. Magnetic Resonance in Chemistry 44: 624.   DOI   ScienceOn
5 Liu, Q. H., Jeong, J.-E., Choi, E. J., Moon, Y. H. and Woo, E.-R. (2006) A new furofuran lignan from Geranium thunbergii. Arch. Pharm. Res. 29: 1109.   과학기술학회마을   DOI   ScienceOn
6 Kircher, H. W. (1980) Triterpenes in organ pipe cactus. Phytochemistry 19: 2707.   DOI   ScienceOn
7 김태정 (1996) 한국의 자원식물 III, p. 205. 서울대학교출판부, 서울
8 배기환 (2000) 원색도감. 한국의 자연시리즈 13 한국의 약용식물, p. 359. 교학사, 서울.
9 Bernini, R., Iavarone, C. and Trogolo, C. (1984) 1-O-${\beta}$-D-Glucopyranosyleucommol, an Iridoid glucoside from Aucuba Japonica. Phytochemistry 23: 1431.   DOI   ScienceOn
10 Mysliwice, J., Kretowski, A., Topolska, J., Stepien, A. and Kinalska, I. (2002) The influence of corticosteroids on IL-6/IL-6R system in patients with graves ophthalmopathy. Pol. Arch. Med. Wewn. 108: 739.
11 Lee, S., Paek, S. H., Kim, S.-K., Kim, B.-K. and Shin, K. H. (2004) Triterpenoids from Orostachys japonicus. Natural Product Sciences 10: 306.   과학기술학회마을
12 Ali, M. S., Mahmud, S., Perveen, S., Ahmad, V. U. and Rizwani, G. H. (1999) Epimers from the leaves of Calophyllum inophyllum. Phytochemistry 50: 1385.   DOI   ScienceOn
13 Leslie Gunatilaka, A. A., Jasmin De Silva, A. M. Y., Sotheeswaran, S., Balasubramaniam, S., Mohamed, I. M. and Wazeer, M. I. M. (1984) Terpenoid and biflavonoid constituents of Calophyllum Calaba and Garcinia Spicata from Sri Lanka. Phytochemistry 23: 323.   DOI   ScienceOn
14 Ragab, A. A., Nalepka, J. L., Bi, Y. and Breenfield, E. M. (2002) Cytokine synergistically induce osteoclast differentiation: support by immortalized or normal calvarial cells. Am. J. Physiol. Cell. Physiol. 283: 679.   DOI   ScienceOn
15 Guo, W. J., Guo, S. X., Yang ,J. S., Chen, X. M. and Xiao, P. G. (2007) Triterpenes and steroids from Armillaria melea Vahl. ex Fr. Biochemical Systematics and Ecology 35: 790.   DOI   ScienceOn
16 Ngouamegne, E. T., Fongang, R. S., Ngouela, S., Boyom, F. F., Rohmer, M., Tsamo, E., Gut, J. and Rosenthal, P. J. (2008) Endodesmiadiol, a Friedelane Triterpenoid, and Other Anti-plasmodial Compounds from Endodesmia calophylloides. Chem. Pharm. Bull. 56: 374.   DOI   ScienceOn
17 Nozaki, H., Suzuki, H., Hirayama, T., Kasai, R., Wu, R. Y. and Lee, K. H. (1986) Antitumour triterpenes of Maytenus Diversifolia. Phytochemistry 25: 479.   DOI   ScienceOn
18 Skehan, P., Storeng, R., Scudiero, D. A., Monks, A., McMahon, J., Vistica, D., Warren, J. T., Bokesch, H. and Kenny, S. (1990) A new colorimetric cytotoxicity assay for anticancer drug screening. J Natl. Cancer Inst. 82: 1107.   DOI
19 Jaki, B. U., Franzblau, S. G., Chadwick, L. R., Lankin, D. C., Zhang, F., Wang, Y. and Pauli, G. F. (2008) Purity Activity Relationships of Natural Products: The Case of Anti-TB Active Ursolic Acid. J. Nat. Prod. 71: 1742.   DOI   ScienceOn
20 Moiteiro, C., Justino, F., Tacares, R., Marcelo-Curto, M. J., Florencio, M. H., Nascimento, M. S. J., Pedro, M., Cerqueira, F. and Pinto, M. M. (2001) Synthetic secofriedelane and friedelane derivatives as inhibitors of human lymphocyte proliferation and growth of human cancer cell lines in vitro. J. Nat. Prod. 64: 1273.   DOI   ScienceOn
21 Qu, L., Chen, X., Lu, J., Yuan, J. and Zhao, Y. (2005) Chemical components of Leptopus chinensis. Chemistry of Natural Compounds 40: 565.
22 Nomura, M., Tokoroyama, T. and Kubota, T. (1981) Biarylheptanids and other comstituents from wood of Alnus japonica. Phytochemistry 20: 1097.   DOI   ScienceOn