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Activation of Innate Immunity by Lepiota procera Enhances Antitumor Activity  

Kim, Doh-Hee (Division of Clinical Research, Medical Institute, Seoul Medical Center)
Han, Kyung-Hoon (Division of Clinical Research, Medical Institute, Seoul Medical Center)
Song, Kwan-Yong (Division of Clinical Research, Medical Institute, Seoul Medical Center)
Lee, Kye-Heui (Division of Clinical Research, Medical Institute, Seoul Medical Center)
Jo, Sun-Young (Department of Food & Nutrition, Yuhan University)
Lee, Seog-Won (Department of Food & Nutrition, Yuhan University)
Yoon, Taek-Joon (Department of Food & Nutrition, Yuhan University)
Publication Information
Korean Journal of Pharmacognosy / v.41, no.2, 2010 , pp. 115-121 More about this Journal
Abstract
The present study was designed to explore an immunostimulating activity of crude extracts of Macrolepiota procera, and a combination therapy of cisplatin and Macrolepiota procera extracts which can potentiate the anti-cancer activity of cisplatin. For these, water extraction of Macrolepiota procera were performed at $4^{\circ}C$(MPE-4) and $100^{\circ}C$(MPE-100). In experimental metastasis of colon26-M3.1 cells, prophylactic intravenous administration of MPE ($80-2,000{\mu}g$/mouse) inhibited tumor metastasis compared with tumor control. Peritoneal macrophages stimulated with MPE produced IL-12 as well as induced tumoricidal activity. In an analysis of NK-cell activity, i.v. administration of MPE ($200{\mu}g$/mouse) significantly augmented NK cytotoxicity to YAC-1 tumor cells. The combination treatments of cisplatin ($20{\mu}g$) and MPE ($100{\mu}g$) exhibited prolongation of lifespan in colon26-M3.1 tumor bearing mouse. These results suggested that MPE stimulate immune system non-specifically and application as adjuvant in cancer treatment.
Keywords
Macrolepiota procera; macrophage; NK-cell; metastasis; synergistic activity;
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