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Anti-inflammatory Effect of MeOH Extract of Cibotium barometz in IFN-$\gamma$ and LPS-stimulated Mouse Peritoneal Macrophage  

Lee, Ji-Young (College of Pharmacy, Woosuk University)
Ko, Sung-Hoon (College of Pharmacy, Woosuk University)
Lee, Yong-Jae (College of Pharmacy, Woosuk University)
Lee, Se-Yeoun (College of Pharmacy, Woosuk University)
Park, Ho-Jun (College of Pharmacy, Woosuk University)
Shin, Tae-Yong (Center for Healthcare Technology Development)
Jeon, Hoon (Center for Healthcare Technology Development)
Publication Information
Korean Journal of Pharmacognosy / v.41, no.2, 2010 , pp. 108-114 More about this Journal
Abstract
The rhizome of Cibotium barometz has been used for variety of bone disease as a traditional medicine. In the present study, we examined the antioxidant and anti-inflammatory activities of 85% methanol extract of C. barometz. C. barometz exhibited potent scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, superoxide radical and nitric oxide radical. In IFN-$\gamma$/LPS-stimulated mouse peritoneal macrophage model, C. barometz suppressed nitric oxide production and IL-6 secretion dose-dependently. Moreover, C. barometz showed decreased iNOS and COX-2 expression without notable cytotoxicity. These results suggest that C. barometz may be an useful agent as an antioxidant and anti-inflammatory agent.
Keywords
Cibotium barometz; antioxidant; anti-inflammatory; nitric oxide;
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1 Laskin, D. L. and Pendino, K. J. (1995) Macrophages and inflammatory mediators in tissue injury. Annu. Rev. Pharmacol. Toxicol. 35: 655-677.   DOI   ScienceOn
2 Seibert, K., Zhang, Y., Leahy, K., Hauser, S., Masferrer, J., Perkins, W., Lee, L. and Isakson, P. (1994) Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc. Natl. Acad. Sci. USA. 91: 12013-12017.   DOI   ScienceOn
3 Frei, K., Malipiero, U. V., Leist, T. P., Zinkernagel, R. M., Schwab, M. E. and Fontana, A. (1989) On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases. Eur. J. Immunol. 19: 689-694.   DOI   ScienceOn
4 Cetkovic-Cvrlje, M. and Eizirik, D. L. (1994) TNF and $IFN{\gamma}$ potentiate the deleterious effects of $IL-1{\beta}$ in moise pancreatic islets mainly via generation of nitric oxide. Cytokine 6: 399-406.   DOI   ScienceOn
5 Garman, R. D., Jacobs, K. A., Clark, S. C. and Raulet, D. H. (1987) B-cell-stimulatory factor 2 (beta 2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells. Proc. Natl. Acad. Sci. USA. 84: 7629-7633.   DOI   ScienceOn
6 Ibrahim, H. R., Hoq, M. I. and Aoki, T. (2007) Ovotransferrin possesses SOD-like superoxide anion scavenging activity that is promoted by copper and manganese binding. Int. J. Biol. Macromo. 41: 631-640.   DOI   ScienceOn
7 Furchgott, R. F. and Zawadzki, J. V. (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373-376.   DOI   ScienceOn
8 Salvemini, D., Korbut, R., Anggard, E. and Vane, J. (1990) Immediate release of a nitric oxide-like factor from bovine aortic endothelial cells by Escherichia coli lipopolysaccharide. Proc. Natl. Acad. Sci. USA. 87: 2593-2597.   DOI   ScienceOn
9 Zamora, R., Vodovotz, Y. and Billiar, T. R. (2000) Inducible nitric oxide synthase and inflammatory diseases. Mol. Med. 6: 347-373.
10 Trowbridge, H. O. and Emling, R. C. Inflammation: a review of the process, 5th Ed. Quintessence Pub. Co., Chicago.
11 Fu, J. Y., Masferrer, J. L., Seibert, K., Raz, A. and Needleman, P. (1990) The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes. J. Biol. Chem. 265: 16737-16740.
12 Lee, Y. S., Kim, H. S., Kim, H. S. and Kim, S. D. (2000) IL-6 mRNA expression in mouse peritoneal macrophages and NIH3T3 fibroblast in response to candida albicans. J. Microbiol. Biotechonol. 10: 8-15.
13 McDaniel, M. L., Kwon, G., Hill, J. R., Marshall, C. A. and Corbett, J. A. (1996) Cytokines and nitric oxide inislet inflammation and diabetes. Proc. Soc. Exp. Biol. Med. 211: 24-32.   DOI
14 Weisz, A., Cicatiello, L. and Esumi, H. (1996) Regulation of the mouse inducible-type nitric oxide synthase gene promoter by interferon-gamma, bacterial lipopolysaccharide and NG-monomethyl-L-arginine. Biochem. J. 316: 209-215.   DOI
15 Corbett, J. A. and MacDaniel, M. L. (1995) Intraislet release of interleukin-1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide syntheses. J. Exp. Med. 181: 559-568.   DOI   ScienceOn
16 Stuehr, D. J., Cho, H. J., Kwon, N. S., Weise, M. F. and Nathan, C. F. (1991) Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD-and FMN-containing flavoprotein. Proc. Natl. Acad. Sci. USA. 88: 7773-7777.   DOI   ScienceOn
17 McCartney-Francis, N., Allen, J. B., Mizel, D. E., Albina, J. E., Xie, Q. W., Nathan, C. F. and Wahl, S. M. (1993) Suppression of arthritis by an inhibitor of nitric oxide synthase. J. Exp. Med. 178: 749-754.   DOI   ScienceOn
18 Muraguchi, A., Hirano, T., Tang, B., Matsuda, T., Horii, Y., Nakajima, K. and Kishimoto, T. (1988) The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. J. Exp. Med. 167: 332-344.   DOI   ScienceOn
19 Park, J. Y. and Pillinger, M. H. (2007) Interleukin-6 in the pathogenesis of rheumatoid arthritis. Bull. NYU. Hosp. Jt. Dis. 65: 4-10.
20 Delgado, A. V., McManus, A. T. and Chambers, J. P. (2003) Production of tumor necrosis factor-alpha, interleukin 1-beta, interleukin 2, and interleukin 6 by rat leukocyte subpopulations after exposure to substance P. Neuropeptides 37: 355-361.   DOI   ScienceOn
21 Yang, M. S. (1986) Studies on the taiwan fork medicine VI. Studies on onitin. Planta Medica (1): 25-27.
22 Karin, M. and Greten, F. R. (2005) NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 5: 749-759.   DOI   ScienceOn
23 Kim, S. T., Han, Y. N., Son, Y. K., Jang, H. S., Kim, S. J. and Shin, J. S. (2002) Isolation of the efficacy constituent for neuronal regeneration from Cibotium barometz. Yakhak. Hoeji. 46: 398-404.   과학기술학회마을
24 Leem, K. H. and Kim, H. C. (2001) Effect of Cibotium barometz on the growth of longitudinal bone in adolescent male rats. Kor. J. Herbology 16: 49-55.
25 Gyamfi, M. A., Yonamine, M. and Aniya, Y. (1999) Free-radical scavenging action of medicinal herbs from Ghana: Thonningia sanguinea on experimentally-induced liver injuries. Gen. Pharmacol. 32: 661-667.   DOI   ScienceOn
26 Squadrito, G. L. and Pryor, W. A. (1998) Oxidative chemistry of nitric oxide: the roles of superoxide, peroxynitrite, and carbon dioxide. Free Radic. Biol. Med. 25: 392-403.   DOI   ScienceOn
27 Phan, H. M., Alpert, J. S. and Fain, M. F. (2008) inflammation, and cardiovascular disease: evidence of a connection. Am. J. Geriatr. Cardio. 17: 101-107.
28 Thornfeldt, C. R. (2008) Chronic inflammation is etiology of extrinsic aging. J. Cosmet. Dermatol. 7: 78-82.   DOI   ScienceOn
29 Ross, R. and Reske-Kunz A. B. (2001) The role of nitric oxide in contact hypersensitivity. intimmunopharmacol. 1: 1469-1478.
30 전국한의과대학 본초학교실 (2006) 본초학, p822-823, 영림사, 서울.
31 Namba, T. (1993) The encycloopedia of Wankan-Yaku with color pictures(I). p86, Hoikusha Pub. Co, Osaka.
32 Higuchi, M., Higashi, N., Taki, H. and Osawa, (1990) T. Cytolytic mechanisms of activated macrophages. Tumor necrosis factor and L-arginine-dependent mechanisms act synergistically as the major cytolytic mechanisms of activated macrophages. J. Immunol. 144: 1425-1431.
33 Masferrer, J. L., Zweifel, B. S., Manning, P. T., Hauser, S. D., Leahy, K. M., Smith, W. G., Isakson, P. C. and Seibert, K. (1994) Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc. Natl. Acad. Sci. USA. 91: 3228-3232.   DOI   ScienceOn
34 Nathan, C. and Xie, Q. W. (1994) Nitric oxide synthases: roles, tolls, and controls. Cell 78: 915-918.   DOI   ScienceOn
35 Bogdan, C. (2001) Nitric oxide and the immune response. Nat. Immunol. 2: 907-916.   DOI
36 Wu, G. and Morris, S. M. (1998) Arginine metabolism: nitric oxide and beyond. Biochem. J. 336: 1-17.   DOI
37 Santos-Gomes, P. C., Seabra, R. M., Andrade, P. B. and Fernandes-Ferreira, M. (2003) Determination of phenolic antioxidant compounds produced by calli and cell suspensions of sage (Salvia officinalis L.). J. Plant Physiol. 160: 1025-1032.   DOI   ScienceOn
38 Surh, Y. J., Chun, K. S., Cha, H. H., Han, S. S., Keum, Y. S., Park, K. K. and Lee, S. S. (2001) Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat. Res. 480-481: 243-268.   DOI   ScienceOn
39 Lee, A. K., Sung, S. H., Kim, Y. C. and Kim, S. G. (2003) Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation. Br. J. Pharmacol. 139: 11-20.   DOI   ScienceOn
40 Nakagawa, T. and Yokozawa, T. (2002) Direct scavenging of nitric oxide and superoxide by green tea. Food. Chem. Toxicol. 40: 1745-1750.   DOI   ScienceOn
41 Sehgal, P. B., Helfgott, D. C., Santhanam, U., Tatter, S. B., Clarick, R. H., Ghrayeb, J. and May, L. T. (1988) Regulation of the acute phase and immune responses in viral disease. Enhanced expression of the beta 2-interferon/hepatocytestimulating factor/interleukin 6 gene in virus-infected human fibroblasts. J. Exp. Med. 167: 1951-1956.   DOI   ScienceOn
42 Murakami, T., Satake, T., Ninomiya, K., Iida, H., Yamauchi, K., Tanaka, N., Saiki, Y. and Chen, C. M. (1980) Pterosinderivate aus der famile pteridaceae. Phytochemistry 19: 1743-1746.   DOI   ScienceOn
43 Nishimoto, N. and Kishimoto, T. (2006) Interleukin 6: From bench to bedside. Nat. Clin. Pract. Rheumatol. 2: 619-626.   DOI   ScienceOn
44 Kishimoto, T. (1989) The biology of interleukin-6. Blood, 74: 1-10.
45 Shalaby, M. R., Waage, A. and Espevik, T. (1989) Cytokine regulation of interleukin 6 production by human endothelial cells. Cell Immunol. 121: 372-382.   DOI   ScienceOn
46 Sanceau, J., Beranger, F., Gaudelet, C. and Wietzerbin, J. (1989) IFN-gamma is an essential cosignal for triggering IFN-beta 2/BSF-2/IL-6 gene expression in human monocytic cell lines. Ann. NY. Acad. Sci. 557: 130-143.
47 Reddy, B. S., Rao, C. V. and Seibert, K. (1996) Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis. Cancer Res. 56: 4566-4569.
48 Gantt, K. R., Goldman, T. L., McCormick, M. L., Miller, M. A., Jeronimo, S. M., Nascimento, E. T., Britigan, B. E. and Wilson, M. E. (2001) Oxidative responses of human and murine macrophages during phagocytosis of Leishmania chagasi. J. Immunol. 167: 893-901.   DOI
49 Kim, Y. H. and Ko, W. S. (2004) Inhibitory effect of spirodela polyrhiza on the mast cell-mediated immediate hypersensitivity. J. Oriental Physiology & Pathology 18: 919-923.   과학기술학회마을