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Sesquiterpene Glycosides from the whole Plant Extract of Youngia japonica  

Kim, Mi-Ri (Korea Research Institute of Chemical Technology)
Cha, Mi-Ran (Korea Research Institute of Chemical Technology)
Choi, Yeon-Hee (Korea Research Institute of Chemical Technology)
Choi, Chun-Whan (Korea Research Institute of Chemical Technology)
Choi, Sang-Un (Korea Research Institute of Chemical Technology)
Kim, Young-Sup (Korea Research Institute of Chemical Technology)
Kim, Young-Kyoon (College of Forest Science, Kookmin University)
Kim, Young-Ho (College of Pharmacy, Chungnam National University)
Ryu, Shi-Yong (Korea Research Institute of Chemical Technology)
Publication Information
Korean Journal of Pharmacognosy / v.41, no.2, 2010 , pp. 103-107 More about this Journal
Abstract
Extensive phytochemical investigation of the methanol extract from the whole plant of Youngia japonica (Asteraceae) led us to the isolation of a new guaiane-type sesquiterpene (1), together with three related guaianolides, youngiajaponicoside A (2), crepiside H (3) and crepeside E (4). The chemical structure of 1 was elucidated by the aid of spectroscopic analyses including 2D-NMR experiments (COSY, HMBC, HMQC and ROESY). The isolated components (1-4) were evaluated for the inhibitory effect on the proliferation of four cultured human tumor cell lines such as A549, SK-OV-3, SK-MEL-2 and HCT-15, in vitro.
Keywords
Youngia japonica; Asteraceae; sesquiterpene; tumor cell proliferation;
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