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Screening on Receptor Tyrosine Kinase Inhibitory Activity of Marine Algae-Derived Symbiotic Microorganisms  

Yun, Keum-Ja (Department of Chemistry, Pukyong National University)
Yang, Guohua (Department of Chemistry, Pukyong National University)
Feng, Zhile (Department of Chemistry, Pukyong National University)
Nenkep, Viviane N. (Department of Chemistry, Pukyong National University)
Xavier, Siwe-Noundou (Department of Chemistry, Pukyong National University)
Leutou, Alain S. (Department of Chemistry, Pukyong National University)
Kim, Gun-Do (Department of Microbiology, Pukyong National University)
Cho, Hee-Yeong (Pharmacology Research Center, Korea Research Institute of Chemical Technology)
Choi, Hong-Dae (Department of Chemistry, Dongeui University)
Son, Byeng-Wha (Department of Chemistry, Pukyong National University)
Publication Information
Korean Journal of Pharmacognosy / v.41, no.1, 2010 , pp. 43-47 More about this Journal
Abstract
In order to screen new receptor tyrosine kinase inhibitor which is expected to be anticancer drug lead, we have investigated receptor tyrosine kinase inhibitory activity on the marine alga-derived symbiotic microorganisms (500 strains). The significant activities (over 70% inhibition at $10\;{\mu}g/ml$) were observed in the extracts of ten strains (Strain No.: MFA018, 019, 206, 242, 325, 335, 343, 344, 354, 356), isolated from marine red algae, five strains (Strain No.: MFA030, 126, 213, 324, 339), isolated from the brown algae, and one strain (Strain No.: MFA272), isolated from the marine green algae, respectively. Among the active strains, MFA019 and 356 showed strong receptor tyrosine kinase inhibitory activity with $IC_{50}$ values of 0.6 and $0.9\;{\mu}g/ml$, respectively.
Keywords
Marine algae; Symbiotic marine microorganism; Receptor tyrosine kinase (RTK) inhibitor; Antitumor drug lead;
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