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Antibacterial Activity and Enhancing Antibiotic Effect of Extract and Fractions from Curcuma longa against MRSA Strain  

Lee, Kyoung-In (Biotechnology Industrialization Center, Dongshin University)
Choi, Cheol-Hee (Research Center for Resistant Cells, Dept. of Pharmacology, Chosun University)
Kim, Sun-Min (Dept. of Oriental Medicine Materials, Dongshin University)
Pyo, Byoung-Sik (Dept. of Oriental Medicine Materials, Dongshin University)
Publication Information
Korean Journal of Pharmacognosy / v.41, no.1, 2010 , pp. 38-42 More about this Journal
Abstract
Curcumin content of butanol fraction from C. longa was found to be 22.4942% of the highest content. However, in DPPH radical scavenging ability and antibacterial activity against methicillin resistance Staphylococcus aureus(MRSA, CCARM3696), ethylacetate fraction contained 2.5791% of curcumin was exhibited highest activity. In comparison of enhancing antibiotic(ampicillin) effect against MRSA, ethanol extract contained 1.7838% of curcumin showed more strong activity. This indicates that the ethanol extract and some fractions from C. longa can have antibacterial activity and enhancing antibiotic effect possibly without curcumin. Appropriate use of antimicrobial agent was important point prior to the development of new antibiotics. And in that sence, extract and fractions of C. longa were worth using as synergist of antibiotics and natural antimicrobial agent.
Keywords
Curcuma longa; MRSA; antibacterial activity; antibiotic;
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Times Cited By KSCI : 10  (Citation Analysis)
Times Cited By SCOPUS : 2
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