Browse > Article

A Study on the Anti-inflammatory and Anti-allergic Effect of Salvia plebeia R. extracts  

Jo, Sun-Young (Department of Food & Nutrition, Yuhan University)
Lee, Ui-Young (Sanyacho-Nongwon)
Kim, Eun-Young (Department of Food & Nutrition, Yuhan University)
Lee, Sue-Jung (Department of Food & Nutrition, Yuhan University)
Her, Jin-Woo (Department of Food & Nutrition, Yuhan University)
Yoon, Taek-Joon (Department of Food & Nutrition, Yuhan University)
Publication Information
Korean Journal of Pharmacognosy / v.41, no.1, 2010 , pp. 31-37 More about this Journal
Abstract
The Salvia plebeia R. which is the biennial plant belonging to the Labiatae department, grows naturally in the Korea entire area. Presently, its extract (SPRE) is known to have an anti-inflammation and anti-allergy activity, but there are a few evidences about it. SPRE inhibits pro-inflammatory cytokine such as TNF-$\alpha$ and IL-6 as well as nitric oxide (NO) production in lipopolysaccharide (LPS) treated- macrophages. The co-administration of SPRE during OVA sensitization significantly reduced total IgE levels in mice. The mice who received SPRE co-administered with OVA showed a significant increase in serum OVA-specific IgG2a/b levels. Spleen-cell cultures harvested from OVA-sensitized mice showed a significant decrease in Th2 cytokine levels with a concomitant increase in Th1 cytokine levels only when SPRE co-administered with OVA. These results demonstrate that SPRE can control the LPS-induced inflammatory reaction and prevent antigen-induced Th2 immune responses in mice.
Keywords
S. plebeia; inflammatoty cytokine; nitric oxide; obalbumin; IgE;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By SCOPUS : 0
연도 인용수 순위
1 Dredge, K., Marriott, J. B., Todryk, S. M. and Dalgleish, A. G. (2002) Adjuvants and the promotion of Th1-type cytokines in tumour immunotherapy. Cancer Immunol. Immunother. 51: 521-531.   DOI   ScienceOn
2 Takano, F., Takata, T., Yoshihara, A., Nakamura, Y., Arima, Y. and Ohta, T. (2007) Aqueous extract of peanut skin and its main constituent procyanidin A1 suppress serum IgE and IgG1 levels in mice-immunized with ovalbumin. Biol. Pharm. Bull. 30: 922-7.   DOI   ScienceOn
3 Park, Y., Chang, Y. S., Lee, S. W., Cho, S. Y., Kim, Y. K., Cho, S. H. and Sung, Y. C. (2001) The enhanced effect of a hexameric deoxyriboguanosine run conjugation to CpG oligodeoxynucleotides on protection against allergic asthma. J. Allergy Clin. Immunol. 108: 570-576.   DOI   ScienceOn
4 Zhu, F. G., Kandimalla, E. R., Yu, D., Tang, J. X. and Agrawal, S. (2004) Modulation of ovalbumin-induced Th2 responses by second-generation immunomodulatory oligonucleotides in mice. Int.. Immunopharmacol. 4: 851-862.   DOI   ScienceOn
5 Bennett, B., Check, I. J., Olsen, M. R. and Hunter, R. L. (1992) A comparison of commercially available adjuvants for use in research. J. Immunol. Methods 153: 31-40.   DOI   ScienceOn
6 Medeiros, K. C., Figueiredo, C. A., Figueredo, T. B., Freire, K. R., Santos, F. A., Alcantara-Neves, N. M., Silva, T. M. and Piuvezam, M. R. (2008) Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice. J. Ethnopharmacol. 119: 41-46.   DOI   ScienceOn
7 Dearman., R, J., Skinner, R. A., Herouet, C., Labay, K., Debruyne, E. and Kimber, I. (2003) Induction of IgE anti-body responses by protein allergens: inter-laboratory comparisons. Food Chem. Toxicol. 4: 1509-1516.
8 Vasilakos, J. P., Smith, R. M., Gibson, S. J., Lindh, J. M., Pederson, L. K., Reiter, M. J., Smith, M. H. and Tomai, M. A. (2000) Adjuvant activities of immune response modifier R-848: comparison with CpG ODN. Cell Immunol. 204: 64-74.   DOI   ScienceOn
9 Choi Y., Park, S. K., Kim, H. M., Kang, J. S., Yoon, Y. D., Han, S. B., Han, J. W., Yang, J. S. and Han, G. (2008) Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model. Exp. Mol. Med. 40: 574-581.   DOI   ScienceOn
10 Dai, Y., Chan, Y. P., Chu, L. M. and Bu, P. P. (2002) Antiallergic and anti-inflammatory properties of the ethanolic extract from Gleditsia sinensis. Biol. Pharm. Bull. 25: 1179-1182.   DOI   ScienceOn
11 Chang, L. P., Lai, Y. S., Wu, C. J. and Chou, T. C. (2009) Liquid perfluorochemical inhibits inducible nitric oxide synthase expression and nitric oxide formation in lipopolysaccharidetreated RAW 264.7 macrophages. J. Phaarmacol. 111: 147-154.
12 Kenny, T. P., Keen, C. L. and Schmitz, H. H., Gershwin, M. E. (2007) Immune effects of cocoa procyanidin oligomers on peripheral blood mononuclear cells. Exp. Biol. Med. 232: 293-300.
13 Yoon, T. J. (2008) Effect of water extracts from root of Taraxacum officinale on innate and adaptive immune response in mice. Korean J. Food & Nutr. 21: 275-282.   과학기술학회마을
14 Brandtzaeg, P. E. (2002) Current understanding of gastrointestinal immunoregulation and its relation to food allergy. Ann. NY Acad. Sci. 964: 13-45.
15 Lim, J. A., Yun, B. W. and Baek, S. H. (2007) Antioxidative Activity and Nitrite Scavenging Ability of Methanol Extract from Salvia plebeia R. Br. Korean J. medicinal Crop Sci. 15: 183-188.   과학기술학회마을
16 Jeon, H. J., Kang, H. J., Jung, H. J., Kang, Y. S., Lim, C. J., Kim, Y. M. and Park, E. H. (2007) Anti-inflammatory activity of Taraxacum officinale. J. Ethnopharmcol. 115: 82-88.
17 Isolauri, E., Huurre, A., Salminen, S. and Impivaara, O. (2004) The allergy epidemic extends beyond the past few decades. Clin. Exp. Allergy 34: 1007-1010.   DOI   ScienceOn
18 Chinen, J. and Shearer, W. T. (2008) Advances in basic and clinical immunology in 2007. J. Allergy Clin. Immunol. 122:3 6-41.   DOI
19 Arancibia, S. A., Beltran, C. J., Aguirre, I. M., Silva, P., Peralta, A. L., Malinarich, F. and Hermoso, M. A. (2007) Tolllike receptors are key participants in innate immune responses. Biol. Res. 40: 97-112.
20 Leon, B. and Ardavin, C. (2008) Monocyte-derived dendritic cells in innate and adaptive immunity. Immunol. Cell Biol. 86: 320-324.   DOI   ScienceOn
21 Lee, H. J., Kang, G, J., Yoon, W, J., Kang, H, K., Kim, Y, S., Kim, S, M. and Yoo, E, S. (2006) Anti-inflammatory Effect of Unripe Fruit of Citrus grandis Osbeck in RAW 264.7 and HaCaT Cells. Kor. J. Pharmacogn. 37: 74-810.   과학기술학회마을