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Alpha-glucosidase Inhibitors from the Branches Extract of Cotinus coggygria  

Cha, Mi-Ran (Korea Research Institute of Chemical Technology)
Park, Jee-Hee (Korea Research Institute of Chemical Technology)
Choi, Yeon-Hee (Korea Research Institute of Chemical Technology)
Choi, Chun-Whan (Korea Research Institute of Chemical Technology)
Hong, Kyung-Sik (Korea Research Institute of Chemical Technology)
Choi, Sang-Un (Korea Research Institute of Chemical Technology)
Kim, Young-Sup (Korea Research Institute of Chemical Technology)
Kim, Young-Kyoon (College of Forest Science, Kookmin University)
Kim, Young-Ho (College of Pharmacy Chungnam National University)
Ryu, Shi-Yong (Korea Research Institute of Chemical Technology)
Publication Information
Korean Journal of Pharmacognosy / v.40, no.3, 2009 , pp. 229-232 More about this Journal
Abstract
The ethanol (EtOH) extract of the branches of Cotinus coggygria (Anacardiaceae) exhibited a significant inhibition on the yeast $\alpha$-glucosidase, one of the key enzymes related with diabetes mellitus, in a dose dependent manner, in vitro. The intensive phytochemical survey of the EtOH extract of the species by way of bioactivity-guided fractionation resulted in the isolation of 1,2,3,4,6-penta-O-galloyl-$\beta$-D-glucose (1) as an active principle responsible for the inhibition on $\alpha$-glucosidase, together with two related components 2 and 3. Compound 1 demonstrated a strong inhibition on the yeast $\alpha$-glucosidase, in vitro and $IC_{50}$ value was calculated as 0.96 mg/ml, when that of a reference drug, acarbose was estimated as 5.3 mg/ml. On the other hand, other related constituents of the species, 1,2,3,6-tetra-O-galloyl-$\beta$-D-glucose (2) and gallic acid (3) were exhibited relatively poor inhibition upon the yeast $\alpha$-glucosidase, respectively.
Keywords
Cotinus coggygria; $\alpha$-glucosidase; pentagalloylglucose; tannin;
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