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Effects of Rumecis Radix Water Extract on Development of Atopic Dermatitis in BALB/c Mice  

Ahn, Ji-Young (Department of Oriental Pharmacy, College of Pharmacy Wonkwang University and Wonkwang-Oriental Medicines Research Institute)
Im, Lee-Rang (Department of Oriental Pharmacy, College of Pharmacy Wonkwang University and Wonkwang-Oriental Medicines Research Institute)
Kim, Jun-Ho (Department of Oriental Pharmacy, College of Pharmacy Wonkwang University and Wonkwang-Oriental Medicines Research Institute)
Park, Jae-Hoon (Oracle Dermatology Clinic)
Kim, Dae-Ki (Department of Immunology, Medical School, Chonbuk National University)
Lee, Young-Mi (Department of Oriental Pharmacy, College of Pharmacy Wonkwang University and Wonkwang-Oriental Medicines Research Institute)
Publication Information
Korean Journal of Pharmacognosy / v.40, no.3, 2009 , pp. 218-223 More about this Journal
Abstract
The roots of Rumecis Radix have been used for the treatment of heat phlegm, jaundice, constipation, scabies and uterine hemorrhage. The aim of this study was to confirm whether Rumecis Radix water extract (RJWE) has a preventive effect on the development of atopic dermatitis (AD) in 2,4-dinitrochlorobenzene (DNCB)-applied BALB/c mice. Oral administration (12.5 mg/kg, 25 mg/kg) and topical application (0.5 mg/mouse, 1.0 mg/mouse) of RJWE decreased the development of AD-like skin lesions, ear swelling, spleen weight and total serum IgE. RJWE significantly also inhibited the infiltration of mast cells in the dorsal skin. Furthermore, the release of histamine from rat peritoneal mast cells (RPMCs) was suppressed significantly. These results suggest that the inhibitory effect of RJWE on AD might be associated with mast cells.
Keywords
Rumecis Radix; atopic dermatitis(AD); mast cells; IgE; 2,4-dinitrochlorobenzene(DNCB);
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1 Arellano, F. M., Wentworth, C. E. and Arana, A. (2007) Risk of lymphoma following exposure to calcineurin inhibitors and topical steroids in patients with atopic dermatitis. J. Invest. Dermatol. 127: 808-816   DOI   ScienceOn
2 Furue, M., Terao, H., Moroi, Y., Koga, T., Kubota, Y., Nakayama, J., Furukawa, F., Tanaka, Y., Katayama, I., Kinukawa, N., Nose, Y. and Urabe, K. (2004) Dosage and adverse effects of topical tacrolimus and steroids in daily management of atopic dermatitis. J. Dermatol. 31: 277-283   DOI   PUBMED   ScienceOn
3 Gao, X. K., Fuseda, K., Shibata, T., Tanaka, H., Inagaki, N. and Nagai, H. (2005) Kampo medicines for mite antigeninduced allergic dermatitis in NC/Nga mice. Evid. Based. Complement. alternat. Med. 2: 191-199   DOI   ScienceOn
4 Cho, K. H. and Kim, H. S. (1980) A Study of Antifungal Activity with Rumex japonicus Huttuyn. Kor. J. Dermatology 18: 383-389
5 Kotani, M., Matsumoto, M., Fujita, A., Higa, S., Wang, W., Suemura, M., Kishimoto, T. and Tanaka T. (2000) Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice. J. allergy Clin. Immunol. 106: 159-166   DOI   ScienceOn
6 Park, Y. K. (2003) Studies on the Anti-oxidative effects of Rumexis Radix. Kor. J. Herbology 18: 269-277
7 Koo, J. and Arain, S. (1998) Traditional Chinese medicine for the treatment of dermatologic disorders. Arch. Dermatol. 134: 1388-1393   DOI   ScienceOn
8 Li, Y. P., Takamiyagi, A., Ramzi, S. T. and Nonaka, S. (2000) Inhibitory effect of Rumex Japonicus Houtt on the porphyrin photooxidative reaction. J. Dermatol. 27: 761-768   DOI   PUBMED   ScienceOn
9 Lee, H. S., Kim, S. K., Han, J. B., Choi, H. M., Park, J. H., Kim, E. C., Choi, M. S., An, H. J., Um, J. Y., Kim, H. M. and Min, B. I. (2006) Inhibitory effects of Rumex japonicus Houtt. on the development of atopic dermatitis-like skin lesions in NC/Nga mice. Br. J. Dermatol. 155: 33-38   DOI   ScienceOn
10 Leung, D. Y. M. (2000) Atopic dermatitis: new insights and opportunities for therapeutic intervention. J. Allergy Clin. Immunol. 105: 860-876   DOI   ScienceOn
11 Bae, K. (2000) Medicinal Plants of Korea. 92. Kyo-Hak Publishing Co., Seoul
12 전국한의과대학 본초학교수 공편저 (1998) 본초학. 398. 영림사, 서울
13 Yildirim, A., Mavi, A. and Kara, A. A. (2001) Determination of antioxidant and antimicrobial activities of Rumex crispus L. extracts. J. Agric. Food Chem. 49:4083-4989   DOI   ScienceOn