Browse > Article

Inhibitory Activity of Medicinal Plants against Differentiation of Osteoclasts  

Lee, Jun-Won (Department of Life Science and Genetic Engineering, Paichai University)
Publication Information
Korean Journal of Pharmacognosy / v.40, no.2, 2009 , pp. 83-88 More about this Journal
Abstract
Bone is continuously remodeled by osteoblasts and osteoclasts. Osteoclasts play an important role in bone metabolism by resorbing the bone matrix. Thus, the compounds inhibiting osteoclasts can improve bone diseases such as osteoporosis. The methanol extracts of 159 herbal medicines were screened for the inhibitory activity against differentiation of osteoclasts. Among the tested extracts, Achuranthis Radix and Corydalis Tuber showed relatively strong inhibitory activity against differentiation of osteoclasts, whereas they have no significant effect on proliferation of osteoclasts.
Keywords
medicinal plants; osteoclast; osteoporosis; differentiation; Achuranthis Radix; Corydalis Tuber;
Citations & Related Records

Times Cited By SCOPUS : 1
연도 인용수 순위
1 Roodman, G. D. (2004) Mechanisms of bone metastasis. N Engl J Med 350: 1655-1664   DOI   PUBMED   ScienceOn
2 Del, Fattore. A., Teti, A. and Rucci, N. (2008) Osteoclast receptors and signaling Arch Biochem Biophys 473: 147-160   DOI   ScienceOn
3 Yasui, T., Uemura, H., Takikawa, M., and Irahara, M. (2003) Hormone replacement therapy in postmenopausal women. J Med Invest 50: 136-145   DOI   PUBMED   ScienceOn
4 Lee, J., Kim, K., Kim, J. H., Jin, H. M., Choi, H. K., Lee, S. H., Kook, H., Kim, K. K., Yokota, Y., Lee, S. Y., Choi, Y. and Kim, N. (2006) Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation. Blood 107: 2686-2693   DOI   ScienceOn
5 Vetrichelvan, T. and Jegadeesan, M. (2003) Effect of alcohol extract of Achyranthes aspera Linn. on acute and subacute inflammation. Phytother Res 17: 77-79   DOI   ScienceOn
6 Kim, S. R., Hwang, S. Y., Jang, Y. P., Park, M. J., Markelonis, G. J., Oh, T. H. and Kim, Y. C. (1999) Protopine from Corydalis ternata has anticholinesterase and antiamnesic activities. Planta Med 65: 218-221   DOI   ScienceOn
7 Lorenzo, J., Horowitz, M. and Choi, Y. (2008) Osteoimmunology: interactions of the bone and immune system. Endocr Rev 29: 403-440   DOI   ScienceOn
8 Bharti, A. C., Takada, Y. and Aggarwal, B. B. (2004) Curcumin (diferuloylmethane) inhibits receptor activator of NFkappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis. J Immunol 172: 5940-59   DOI   PUBMED   ScienceOn
9 생약학 (2006) 생약학교재편찬위원회. 동명사, 서울
10 Teitelbaum, S. L. (2000) Bone resorption by osteoclasts. Science 289: 1504-1508   DOI   PUBMED   ScienceOn
11 Potter, S. M., Baum, J. A., Teng, H., Stillman, R. J., Shay, N. F. and Erdman, J. W. Jr. (1998) Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 68: 1375S–1379S   DOI   PUBMED
12 Wattel, A., Kamel, S., Prouillet, C., Petit, J. P., Lorget, F., Offord, E. and Brazier, M. (2004) Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF kappa B and AP-1. J Cell Biochem 92: 285-295   DOI   ScienceOn
13 Breitman, P. L., Fonseca, D., Cheung, A. M. and Ward, W. E. (2003) Isoflavones with supplemental calcium provide greater protection against the loss of bone mass and strength after ovariectomy compared to isoflavones alone. Bone 33:597-605   DOI   ScienceOn
14 Lee, J., Lee, S. H., Choi, Y. and Kim, N. (2007) The negative role of IdS in osteoclastogenesis. Adv Exp Med Biol 602: 23-31   DOI   PUBMED