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Effect of Orostachys japonicus A. Berger on Apoptosis Induction of Human Leukemia HL60 Cells  

Oh, Chan-Ho (Department of Food & Biotechnology, Woosuk University)
Bae, Jin-Beom (Department of Food & Biotechnology, Woosuk University)
Kim, Nam-Seok (Department of Food & Biotechnology, Woosuk University)
Jeon, Hoon (College of Pharmacology, Woosuk University)
Han, Kwang-Soo (Department of Alternative Medicine, Woosuk University)
Lee, Moon-Jun (College of Environmental & Bioresource Sciences, Chonbuk National University)
Kwon, Jin (Department of Prosthetics and Orthotics, Korea National College of Rehabilitation and Welfare)
Publication Information
Korean Journal of Pharmacognosy / v.40, no.2, 2009 , pp. 118-122 More about this Journal
Abstract
Methanol extracts of Orostachys japonicus A. Berger (OAB) were found to exhibit apoptosis induction of HL60 human acute promyelocytic leukemia cells. Treatment of OAB exerted strong cytotoxicity against HL60 cells. OAB induced DNA fragmentation of HL60 cells in a dose dependent manner. Nitric oxide production were also increased in OAB-treated RAW264.7 macrophage cell lines. Treatment of OAB increased the expression of p53 and iNOS gene and the expression of p53, $NF-{\kappa}B$ and iNOS protein in cultured HL60 and RAW264.7 cells. These results suggest that OAB are effective on strong anti-cancer properties and can be useful as a chemo-preventive agents.
Keywords
Orostachys japonicus A. Berger; HL60 leukemia cell; apoptosis; p53; $NF-{\kappa}B$;
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Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By SCOPUS : 1
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