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Anti-hyperlipidemic Effects of the Flavonoid-rich Fraction from the Methanol Extract of Orostachy japonicus in Rats  

Kim, Sei-Gun (Department of Oriental Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University)
Choi, Jong-Won (College of Pharmacy, Kyungsung University)
Park, Hee-Juhn (Department of Pharmaceutical Engineering, Sangji University)
Lee, Sang-Myung (KT&G Central Research Institute)
Jung, Hyun-Ju (Department of Oriental Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University)
Publication Information
Korean Journal of Pharmacognosy / v.40, no.1, 2009 , pp. 51-58 More about this Journal
Abstract
The anti-hyperlipidemic effects of an ethyl acetate fraction from Orostachy japonicus in a high lipid diet-induced hyperlipidemic rat model were assessed. The fraction, which contained kaempferol, astragalin, and isoquercitrin, was associated with significant weight loss and reduction of lipid contents in serum and liver tissues. The fraction, which contains mainly flavonoids, diminished the levels of malondialdehyde and hydroxyl radical, and increased the anti-oxidative enzyme activities of superoxide dismutase, catalase, and glutathione peroxidase. Reduced bleeding and plasma clotting times resulting from the administration of the ethyl acetate fraction may reduce cardiovascular disease associated with hyperlipidemia.
Keywords
Orostachys japonicus; Crassulaceae; Flavonoid; Hyperlipidemic effect; Oxidative stress;
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