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Augmentation of Immune Responses by Oral Administration of Gynostemma pentaphyllum Ethanol Extract  

Im, Sun-A (College of Pharmacy, Chungbuk National University)
Choi, Hyun-Suk (College of Pharmacy, Chungbuk National University)
Hwang, Bang-Yeon (College of Pharmacy, Chungbuk National University)
Lee, Myung-Koo (College of Pharmacy, Chungbuk National University)
Lee, Chong-Kil (College of Pharmacy, Chungbuk National University)
Publication Information
Korean Journal of Pharmacognosy / v.40, no.1, 2009 , pp. 35-40 More about this Journal
Abstract
The immunomodulatory activities of the ethanol extract of Gynostemma pentaphyllum, termed hereafter as GPE, were examined in immunosuppressed mice as well as in normal mice in the present study. Oral administration of GPE into mice prevented dexamethasone (DEX)-induced immunosuppression as determined by the mitogen-induced proliferation of the splenocytes and the the cytokine production (TNF-$\alpha$, IL-$1{\beta}$) in the whole blood culture. In addition, oral administration of GPE increased antitumor host defense in mice implanted with sarcoma-180 tumor cells. The immunoaugmenting activity of orally administered GPE was also confirmed in mice immunized with ovalbumin (OVA). Mice that were orally administered with GPE generated much more potent OVA-specific cytotoxic T lymphocyte (CTL) responses upon intravenous OVA injection compared to the untreated controls. These results demonstrate that oral administration of the ethanol extract of Gynostemma pentaphyllum could be useful to increase host defense in immunocompromised situations such as stress- or tumor-induced immunosuppression.
Keywords
Gynostemma pentaphyllum; Dexamethasone; Immunomodulation; Antitumor activity; Cytotoxic T lymphocytes;
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