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Anti-proliferative Effect of the Rhizome Extract of Alpinia officinarum on Cultured Human Tumor Cell Lines  

Lee, Ho-Sung (Korea Research Institute of Chemical Technology)
Cha, Mi-Ran (Korea Research Institute of Chemical Technology)
Choi, Chun-Whan (Korea Research Institute of Chemical Technology)
Choi, Sang-Un (Korea Research Institute of Chemical Technology)
Kim, Young-Sup (Korea Research Institute of Chemical Technology)
Kim, Young-Kyoon (College of Forest Science, Kookmin University)
Kim, Young-Ho (College of Pharmacy Chungnam National University)
Yon, Gyu-Hwan (Korea Research Institute of Chemical Technology)
Ryu, Shi-Yong (Korea Research Institute of Chemical Technology)
Publication Information
Korean Journal of Pharmacognosy / v.39, no.4, 2008 , pp. 347-351 More about this Journal
Abstract
The methanol (MeOH) extract of the rhizome of Alpinia officinarum Hance (Zingiberaceae) demonstrated a potent inhibition on the proliferation of cultured human tumor cell lines such as MES-SA (human uterine carcinoma cell line), MESSA/DX5 (multidrug resistant subline of MES-SA), HCT-15 (human colorectal adenocarcinoma cell line), HCT15/CL02 (multidrug resistant subline of HCT15). The MeOH extract was fractionated into four portions by serial solvent partition, ie., methylene chloride (CH2Cl2) soluble part, ethylacetate (EtOAc) soluble part, n-butanol (BuOH) soluble part and remaining water layer. Among them, the $CH_2Cl_2$ soluble part of the extract exhibited a most potent inhibition on the proliferation of tested tumor cell lines. Bioassay-guided fractionation of the $CH_2Cl_2$ soluble part led to the isolation of five diarylheptanoid and two flavonoid constituents, i. e., galangin (1), 7-(4"-hydroxy-3"-methoxyphenyl)-1-phenylhept-4-en-3-one (2), 1,7-diphenyl-5-hydroxy-3-heptanone (3), trans,trans-1-(3'-methoxy-4'-hydroxyphenyl)-7-phenyl-5-ol-4,6-dien-3-heptanone (4), 5-methoxy-7-(4"-hydroxy-3"-methoxyphenyl)-1-phenyl-3-heptanone (5), kaempferide (6), 5-hydroxy-7-(4"-hydroxy-3"-methoxyphenyl)-1-phenyl-3-heptanone (7). Structures of the isolated active components (1 - 7) were established by chemical and spectroscopic means.
Keywords
Alpinia officinarum; Zingiberaceae; diarylheptanoid; flavonoid; cytotoxic activity;
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Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By SCOPUS : 1
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