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Antioxidative Constituents from the Whole Plants of Euphorbia supina  

Hong, Hyun-Kyung (College of Pharmacy, Sungkyunkwan University)
Kwak, Jong-Hwan (College of Pharmacy, Sungkyunkwan University)
Kang, Se-Chan (Department of Natural Medicine Resources, Semyung University)
Lee, Jong-Wook (College of Pharmacy, Sungkyunkwan University)
Park, Jong-Hyuk (College of Pharmacy, Sungkyunkwan University)
Ahn, Jong-Woong (Division of Marine Environment and Bioscience, Korea Maritime University)
Kang, Hye-Sook (Research Institute of Marine Science and Technology, Korea Maritime University)
Choung, Eui-Su (College of Pharmacy, Sungkyunkwan University)
Zee, Ok-Pyo (College of Pharmacy, Sungkyunkwan University)
Publication Information
Korean Journal of Pharmacognosy / v.39, no.3, 2008 , pp. 260-264 More about this Journal
Abstract
Eight compounds were isolated from the EtOAc soluble fraction of Euphorbia supina MeOH extract as the radical scavengers for antioxidant activity. Their structures were identified as kaempferol (1), quercetin (2), juglanin (3), avicularin (4), astragalin (5), isoquercitrin (6), hyperin (7), and nicotiflorin (8) by spectroscopic analysis. The antioxidant activity was evaluated by the ORAC (oxygen radical absorbance capacity) assay, which measures scavenging activity against peroxy radicals induced by 2,2'-azobis (2-methylpropionamidine) dihydrochloride, and the ORAC value is expressed as relative trolox equivalent. Compounds 4, 6, and 7 exhibited potent antioxidant activity, whereas the other compounds showed weaker activity than trolox.
Keywords
Euphorbia supina; flavonoid; antioxidant activity; ORAC assay;
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Times Cited By KSCI : 8  (Citation Analysis)
Times Cited By SCOPUS : 3
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