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Effects of Antidiabetic and GLUT4 gene Expression of Acanthopanax senticosus Extracts  

Choung, Eui-Su (College of Pharmacy, SungKyunKwan University)
Park, Jong-Phil (College of Pharmacy, SungKyunKwan University)
Choi, Han (Gyeong-gi Pharmaceutical Research Center)
Jang, Gyeong-Sun (Ilsongjung Co., Ltd.)
Kang, Shin-Ho (Dept. of Natural Medicine Resources, Semyung University)
Kang, Se-Chan (Dept. of Natural Medicine Resources, Semyung University)
Zee, Ok-Pyo (College of Pharmacy, SungKyunKwan University)
Publication Information
Korean Journal of Pharmacognosy / v.39, no.3, 2008 , pp. 228-232 More about this Journal
Abstract
Antidiabetic effects of an aqueous and solvent extract prepared from the root, stem and fruit parts of Acanthopanax senticosus, were investigated in experimental Streptozotocin (STZ)-induced diabetic rats model. The n-butanol and water extracts of A. senticosus were orally administrated once a day for 6 days. The n-butanol extracts of fruit (FB) showed highest efficiency than other groups (water extracts of stem, root and fruit; butanol extracts of stem, root) on serum glucose values in the STZ-induced diabetic rats. We have studied gene expression of glucose transporter genes in C2C12 skeletal muscle cell line during differentiation treated by the n-butanol and water extracts of A. senticosus, SW, RW, FW, SB, RB and FB. The GLUT4 gene was high expressed by FB treatment. These findings suggest that FB of A. senticosus have GLUT4 gene expression activity for glucose homeostasis and may have beneficial effects on blood glucose lowering in the diabetic patients.
Keywords
Streptozotocin; Acanthopanax senticosus; Antidiabetic effect; GLUT2; GLUT4;
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