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Development of the Standard Analytical Methods for Ginkgo biloba Leaf Extract  

Kim, Seung-Hyun (Institute for LifeScience, Elcom Science Co. Ltd.)
Kim, Dae-Hyun (Institute for LifeScience, Elcom Science Co. Ltd.)
Park, Jin-Ho (Institute for LifeScience, Elcom Science Co. Ltd.)
Oh, Mi-Hyune (Department of Herbal Medicines Evaluation, Division of Herbal Medicinal Products, Korea Food & Drug Administration)
Cho, Chang-Hee (Department of Herbal Medicines Evaluation, Division of Herbal Medicinal Products, Korea Food & Drug Administration)
Baek, Ju-Hyun (Department of Herbal Medicines Evaluation, Division of Herbal Medicinal Products, Korea Food & Drug Administration)
Cho, Jung-Hee (Department of Herbal Medicines Evaluation, Division of Herbal Medicinal Products, Korea Food & Drug Administration)
Kim, Tae-Bum (College of Pharmacy, Seoul National University)
Lee, Ki-Yong (College of Pharmacy, Seoul National University)
Kim, Young-Choong (College of Pharmacy, Seoul National University)
Sung, Sang-Hyun (College of Pharmacy, Seoul National University)
Publication Information
Korean Journal of Pharmacognosy / v.39, no.3, 2008 , pp. 218-222 More about this Journal
Abstract
This study was carried out to establish standard analytical methods for Ginkgo biloba leaf extract. Ginkgo flavonoids, terpene lactones, ginkgolic acids were employed as reference compounds for analytical method. Analytical method of US Pharmacopoeia was adopted for flavonoids and terpene lactones, and a new method was developed for ginkgolic acids. Analytical methods established in this study could be applied to a reasonable and unified quality control of G. biloba leaf extract.
Keywords
Ginkgo biloba leaf extract; standard analytical method;
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1 Mesbah, M.K., Khalifa, S. I., El-Gindy, A and Tawfik, K.A. (2005) HPLC determination of certain flavonoids and terpene lactones in selected Ginkgo biloba L. phytopharmaceuticals. Farmaco., 60: 583-590   DOI   ScienceOn
2 Persson, J., Bringlv, E., Nilsson, L. G., and Nyberg, L. (2004) The memory-enhancing effects of Ginseng and Ginkgo biloba in healthy volunteers. Psychopharmacology, 172: 430-434   DOI
3 Mustafa, O., Brendan, M. and Pei, C. (2007) Comparison of the terpene lactones and flavonoids contents in G. Biloba commercial samples and the NIST standard reference materials using LC/UV/MS. J. Food Drug Anal., 15: 55-62
4 식품의약품안전청 (2007) 대한약전외의약품등기준(KPC) 개정에 따른 생약(한약)제제의 규격 설명회 참고자료, 30-35, 46-52
5 The United States Pharmacopeial Convention (2007) United States Pharmacopoeia, 937-938
6 Dubber, M. J. and Kanfer, I. (2005) The simultaneous determination of selected flavonol glycosides and aglycones in Ginkgo biloba oral dosage forms by high-performance liquid chromatography-electrospray ionisation-mass spectrometyr. J. Pharm. Biomed. Anal., 37: 723-731   DOI   ScienceOn
7 Chung, H. S., Harris, A., Kristinsson, J. K., Ciulla, T. A., Kagemann, C. and Ritch, R. (1999) Ginkgo biloba extract increases ocular blood flow velocity. J. Ocul. Pharmacol. Ther., 15: 233-240   DOI   ScienceOn
8 Zhang, X., Ouyang, Z., Yang, K., Chen, J. (2003) Isolation and HPLC analysis of ginkgolic acid. Zhong Yao Cai, 26: 557-559
9 Fuzzati, N., Pace, R. and Villa, F. (2003) A simple HPLC-UV method for the assay of ginkgolic acids in Ginkgo biloba extracts. Fitoterapia, 74: 247-256   DOI   ScienceOn
10 Lichtblau, D., Berger, J. M. and Nakanishi, K. (2002) Efficient extraction of ginkgolides and biloblide from Ginkgo biloba leaves. J. Nat. Prod., 65: 1501-1504   DOI   ScienceOn
11 Hausen, B.M. (1998) The sensitizing capacity of ginkgolic acids in guinea pigs. Am. J. Contact Dermat., 9: 146-148   DOI   ScienceOn
12 De Feudis, F.V. (1991) Ginkgo biloba Extract (EGb 761): Pharmacological activities and clinical applications. Paris, France, Elsevier
13 식품의약품안전청 (2007) 대한약전외의약품등기준, 1165-1166
14 Deng, F. and Zito, S. W. (2003) Development and validation of a gas chromatographic-mass spectrometric method for simultaneous identification and quantification of marker compounds including bilobalide, ginkgolides and flavonoids in Ginkgo biloba L. extract and pharmaceutical preparations. J. Chromatogr. A, 986: 121-127   DOI   ScienceOn
15 Ding, C., Chen, E., Zhou, W. and Lindsay, R. C. (2004) A Method for extraction and quantification of ginkgo terpene trilactones. Anal. Chem., 76: 4332-4336   DOI   ScienceOn
16 Van Beek, T. A. and Wintermans, M. S. (2001) Preparative isolation and dual column high-performance liquid chromatography of ginkgolic acids from Ginkgo biloba. J. Chromatogr. A, 930: 109-117   DOI   ScienceOn