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Inhibitory Effect of Enteromorpha linza on the Melanogenesis in B16 Melanoma Cells  

Cho, Young-Ho (Department of Pharmaceutical Engineering, Konyang University)
Publication Information
Korean Journal of Pharmacognosy / v.39, no.3, 2008 , pp. 174-178 More about this Journal
Abstract
Melanin is a polymer of phenol which produces hyperpigmentation in the skin. Melanin synthesis is catalyzed by the enzyme tyrosinase. To investigate the whitening activity of the fractions from the ethanol extract of Enteromorpha linza, we studied the inhibitory effect on the tyrosinase activity and melanogenesis in the B16/F1 melanoma cells. The inhibition ratio of tyrosinase activity of ethylacetate fraction from E. linza was as strong as that of kojic acid, a positive control. Also, the melanin production was significantly inhibited by the ethylacetate fraction in a dose dependent manner. The ethylacetate fraction showed the highest activity in the fractions and as strong activity as that of arbutin, a positive control. From these results, we suggest that the E. linza extract might be able to apply to cosmetic and medical fields.
Keywords
Enteromorpha linza; melanogenesis; tyrosinase; melanin;
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1 Cho, K. J., Lee, Y. S. and Ryu, B. H. (1990) Antitumor effect and immunology activity of seaweeds toward sarcoma-180. Bull. Korean Fish. Soc. 23: 345-352
2 Chun, H. J., Hwang, S. G., Jeong, D. H., Baek, S. H., Jeon, B. H. and Woo, W. H. (2002) Butyl alcohol extract from Caesalpinia sappan L. regulates melanogenesis in B16/F10 melanoma cells. Yakhak Hoeji. 46: 137-142
3 Park, Y. J., Yoon, M. Y., Lim, H. W., Lee, J. Y., Kim, C. J. and Sim, S. S. (2004) Effects of hot-water extracts from Laminaria japonicus on melanin production in B16 melanoma cells. Yakhak Hoeji. 48: 374-378
4 Kang, H. S., Kim, H. R., Byun, D. S., Son, B. W., Nam, T. J. and Choi, J. S. (2004) Tyrosinase inhibitors isolated from the edible brown alge Ecklonia stolonifera. Arch. Pharm. Res. 27: 1226-1232   DOI   ScienceOn
5 Fujiware, Y., Sahashi, Y., Artro, M., Hasegawa, S., Akimoto, K., Ninomiya, S., Sakaguchi, Y. and Seyama, Y. (2004) Effect of simultaneous administration of vitamin C, L-cysteine and vitamin E on the melanogenesis. Biofactors. 21: 415-418   DOI
6 Englaro, W., Rezzonico, R., Durand-Clement, M., Lallemand, D., Ortonne, J. P. and Ballotti, R. (1995) Mitiogen-activated protein kinase pathway and AP-1 are activated during cAMP-induced melanogenesis in B-16 melanoma cells. J. Biol. Chem. 270: 24315-24320   DOI   ScienceOn
7 Choi, B. W., Lee, B. H., Kang, K. J., Lee, E. S. and Lee, N. H. (1998) Screening of the tyrosinase inhibitors from marine algae and medicinal plants. Kor. J. Pharmacogn. 29: 237-242   과학기술학회마을
8 Chakraborty, A. K., Funasaka, Y., Komoto, M. and Ichihashi, M. (1998) Effect of arbutin on melanogenic proteins in human. Pigment Cell Res. 11: 206-212   DOI   ScienceOn
9 Hearing, V. J. (1999) Biochemical control of melanogenesis and melanosomal organization. Soc. Invest. Dermatol. 4: 24-28   DOI   ScienceOn
10 Kim, K. Y., Ahn, Y. S. and Lee, I. K. (1991) Growth and morphology of Enteromorpha linza (L.) J. Ag. And E. prolifera (Muller) J. Ag. (Ulvales, Chlorophyceae). Kor. J. Phycol. 6: 31-45
11 Cabanes, J., Chazarra, S. and Garci-Carmona, F. (1994) Kojic acid, a cosmetic skin whitening agent, is a slow-binding inhibitor of catecholase activity of tyrosinase. J. Pharm. Pharmacol. 46: 982-985   DOI   ScienceOn
12 Shuji, K., Hideo, Y., Kimiko, M. and Yoshio, U. (1995) Inhibitory effect of sodium 5,6-benzylidene ascorbate(BSA) on the elevation of melanin biosynthesis induced by ultraviolet-A(UVA) light in cultured B16 melanoma cells. Biol. Pharm. Bull. 18: 1076-1080   DOI   ScienceOn
13 Hong, J. S., Kwon, Y. J., Kim, Y. H., Kim, M. K., Park, I. W. and Kang, K. H. (1991) Fatty acid composition of Miyeok (Undaria pinnatifida) and Pare (Enteromorpha compressa). Korean J. Food & Nutri. 20: 376-380   과학기술학회마을
14 Maeda, K. and Fukuda, M. (1991) In vitro effectiveness of several whitening cosmetic components in human melanocyte. J. Soc. Cosmet. Chem. 42: 361-368
15 Lee, J. K., Jung, H. M. and Kim, S. Y. (2003) 1,8-Dihydroxynaphthalene (DHN)-melanin biosynthesis inhibitors increase erythritol production in Torula corallina, and DHN-melanin inhibits erythrose reductase. Appl. Envir. Microbiol. 69: 3427-3434   DOI
16 Mosmann, T. (1983) Rapid colorimetric assay for the cellular growth and survival: application to proliferation and cytotoxic assay. J. Immunol. Methods. 65: 55-63   DOI   ScienceOn
17 Park, N. H., Hong, Y. K. and Cho, J. Y. (2006) Screening antiinflammatory actinomycetes isolated from seaweeds and marine sediments. J. Kor. Fish. Soc. 39: 333-337   과학기술학회마을   DOI
18 Ryu, B. H., Kim, D. S., Cho, K. J. and Sin, D. B. (1989) Antitumor activity of seaweeds toward sarcoma-180. Korean J. Food Sci. Technol. 21: 595-600   과학기술학회마을
19 Kim, J. J., Cho, Y. H., Park, S. M., Lee, K. E., Lee, J. J., Lee, B. C., Pyo H. B., Song, K. S., Park, H. D. and Yun, Y. P. (2004) Antioxidants and inhibitor of Matrix metalloproteinase-1 expression from leaves of Zostera marina L. Arch. Pharm. Res. 27: 177-183   DOI   ScienceOn
20 Marmol, V. del. and Beermann, F. (1996) Tyrosinase and related proteins in mammalian pigmentation. FEBS Lett. 381: 165-168   DOI   ScienceOn
21 Martinez-Esparza, M., Jimenez-Cervantes, C., Solano, F., Lozano, J. A. and Garcia-Borron, J. C. (1998) Mechanisms of melanogenesis inhibition by tumor necrosis factor- in B16/F10 mouse melanoma cells. Eur. J. Biochem. 255: 139-146   DOI   ScienceOn
22 Hosoi, J., Abe, E., Suda, T. and Kuroki, T. (1985) Regulation of melanin synthesis of B16 mouse melanoma cells by 1 alpha, 25-dihydroxyvitamin D3 and retinoic acid. Cancer Res. 45: 1474-1478
23 Mun, Y. J., Yoo, H. J., Lee, K. E., Kim, J. H., Pyo, H. B. and Woo, W. H. (2005) Inhibitory effect on the melnogenesis of Capsosiphon fulvescens. Yakhak Hoeji. 49: 375-379   과학기술학회마을