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Screening of Inhibitory Effect on Aldose Reductase of Korean Herbal Medicines and Preventive Effect of Catalpa bignonioides against Xylose-induced Lens Opacity (I)  

Lee, Yun-Mi (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Kim, Nan-Hee (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Kim, Jong-Min (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Kim, Young-Sook (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Jang, Dae-Sik (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Kim, Joo-Hwan (Department of Life Science, Daejeon University)
Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
Kim, Jin-Sook (Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine)
Publication Information
Korean Journal of Pharmacognosy / v.39, no.3, 2008 , pp. 165-173 More about this Journal
Abstract
Aldose reductase (AR), the principal enzyme of the polyol pathway, has been shown to play an important role in the diabetic complications, including diabetic cataract. The inhibitors of AR, therefore, would be potential agents for prevention of diabetic complications. As part of our ongoing project directed toward the discovery of preventive and/or treatment for diabetic complications, 48 Korean herbal medicines have been investigated with an in vitro evaluation system using aldose reductase inhibitory activities. Of these, 12 herbal medicines exhibited a significant inhibitory activity against aldose reductase. Particularly, seven herbal medicines, i.e., Eurya japonica, Chrysanthemum indicum, Akebia quinata, Saururus chinensis, Catalpa bignonioides, Lonicera japonica, Vitex rotundifolia showed two times more potent inhibitory activity than the positive control 3.3-tetramethyleneglutaric acid (TMG). In addition, Catalpa bignonioides showed the retardation of cataract-opacification of the lens of the eye under diabetic condition by xylose. Therefore, this result may provide a potential therapeutic approach for preventing and treating diabetic cataracts.
Keywords
Diabetic cataract; Aldose reductase; AGEs; Korean herbal medicines;
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Times Cited By KSCI : 4  (Citation Analysis)
Times Cited By SCOPUS : 7
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1 Son, K. H., Park, J. O., Chung, K. C., Chang, H. W., Kim, H. P., Kim, J. S. and Kang, S. S. (1992) Flavonoids from aerial parts of Lonicera japonica. Arch Pharm. Res. 15: 365-370   DOI
2 Kang, K. H. (1998) Volatile flavor components of chestnut honey produced in Korea. Agri. Chem. Biotechnol. 41: 84-88   과학기술학회마을
3 Jesus Angel, de la F. and Sonia, M. (2003) Aldose reductase inhibitors from natural sources. Nat. Prod. Rep. 20: 243-251   DOI   ScienceOn
4 Hotta, N., Toyota, T., Matsuoka, K., Shigeta, Y., Kikkawa, R., Kaneko ,T., Takahashi, A., Sugimura, K., Koike, Y., Ishii, J. and Sakamoto, N. (2001) Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled doubleblind parallel group study. Diabetes Care 24: 1776-1782   DOI
5 Matsuda, H., Morikawa, T., Toguchida, I., Harima, S. and Yoshikawa, M. (2002) Medicinal flowers. VI. Absolute stereostructures of two new flavanone glycosides and a phenylbutanoid glycoside from the flowers of Chrysanthemum indicum L.: their inhibitory activities for rat lens aldose reductase. Chem. Pharm. Bull. 50: 972-975   DOI   ScienceOn
6 David, R. T., Elizabeth, J. S. and Lara, T. D. (1994) Aldose reductase inhibitors and their potential for the treatment of diabetic complications. Trends Pharmacol. Sci. 15: 293-297   DOI   ScienceOn
7 Lee, Y. S., Lee, S. H., Kim, B. K. and Shin, K. H. (2004) Screening for aldose reductase inhibitory activity of extracts of the marine plants from Korea. Algae 19: 349-352   DOI
8 Dufrane, S. P., Malaisse, W. J. and Sener, A. (1984) A micromethod for the assay of aldose reductase, its application to pancreatic islets. Biochem. Med. 32: 99-105   DOI   ScienceOn
9 Collins, J. B. and Corder, C. N. (1977) Aldose reductase and sorbitol dehydrogenase distribution in substrctures of normal and diabetic rats lens. Invest. Ophthamol. Visual Sci. 16: 242-243
10 Son, K. H., Kim, J. S., Kang, S. S., Kim, H. P.and Chang, H. W. (1994) Isolation of flavonoids from Lonicera japonica. Kor. J. Pharmacog. 25: 24-27   과학기술학회마을
11 Rao, K. V. and Reddy, G. C. (1990) Chemistry of Saururus cernuus, V. sauristolactam and other nitrogenous constituents. J. Nat. Prod. 53: 309-312   DOI
12 Yoshikawa, M., Morikawa, T., Toguchida, I., Harima, S. and Matsuda, H. (2000) Medicinal flowers. II. Inhibitors of nitric oxide production and absolute stereostructures of five new germacrane-type sesquiterpenes, kikkanols D, D monoacetate, E, F, and F monacetate from the flowers of Chrysanthemum indicum L. Chem. Pharm. Bull. 48: 651-656   DOI   ScienceOn
13 Jung, S. H., Lim, S. S., Lee, S. H., Lee, Y. S., Shin, K. H. and Kim, Y. S. (2003) Aldose reductase inhibitory activity of methanol extracts from the Korean plants. Nat. Prod. Sci. 9: 34-37   과학기술학회마을
14 Kinoshita, J. H., Dvornik, D., Kraml, M. and Gabbay, K. H. (1968) The effect of an aldose reductase inhibitor on the galactose-exposed rabbit lens. Biochim. Biophys. Acta. 24: 158: 472-475   DOI
15 Chung, Y. S., Choi, Y. H., Lee, S. J., Choi, S. A., Lee, J. H., Kim, Harriet and Hong, E. K. (2005) Water extract of Aralia elata prevents cataractogenesis in vitro and in vivo. J. Ethnopharmacol. 101: 49-54   DOI   ScienceOn
16 Varma, S. D. and Richards, R. D. (1984) Etiology of cataracts in diabetics. Int. Ophthalmol. Clin. 24: 93-110
17 Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Radall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275
18 Chand, D., H. EL-Aguizy, Richards R.D. and Varma S.D.(1982) Sugar cataracts in vitro: implication of oxidative stress and aldose reductase I. Exp. Eye Research 35: 491-497   DOI   ScienceOn
19 Munoz-Mingarro, D., Acero, N., Llinares, F., Pozuelo, J. M., Galan de Mera, A., Vicenten, J. A., Morales, L., Alguacil, L. F. and Perez, C. (2003) Biological activity of extracts from Catalpa bignonioides Walt. (Bignoniaceae) J. Ethnopharmacol. 87: 163-167   DOI   ScienceOn
20 Spector, A., Wang, G. M. and Wang, R. R. (1993) The prevention of cataract by oxidative stress in cultured rat lenses. II. Early effects of photochemical stress and recovery. Exp. Eye Research 57: 659-667   DOI   ScienceOn
21 Yoshioka, T., Inokuchi, T., Fujioka, S. and Kimura, Y. (2004) Phenolic compounds and flavonoids as plant growth regulators from fruit and leaf of Vitex rotundifolia. Z. Naturforsch. 59: 509-514
22 Shin, H. K., Kang, S. S., Kim, H. J. and Shin, S. W. (1994) Isolation of an aldose reductase inhibitor from the fruits of Vitex rotundifolia. Phytomedicine. 1: 46-48
23 Kyseloa, A., Stefek, M. and Bauer, V. (2004) Pharmacological prevention of diabetic cataract. J. Diabetes Complicat. 18: 129-140   DOI   ScienceOn
24 Kwak, W. J., Han, C. K., Chang, H. W., Kim, H. P., Kang, S. S. and Son, K. H. (2003) Loniceroside C, an Antiinflammatory Saponin from Lonicera japonica. Chem. Pharm. Bull. 51: 333-335   DOI   ScienceOn
25 Jung, S. H., Kang, S. S., Shin, K. H. and Kim, Y. S. (2004) Inhibitory effects of naturally occurring flavonoids in rat lens aldose reductase. Nat. Prod. Sci. 10: 35-39
26 Yoshikawa, M., Morikawa, T., Murakami, T., Toguchida, I., Harima, S. and Matsuda, H. (1999) Medicinal flowers. I. Aldose reductase inhibitors three new eudesmane-type sesquiterpenes, kikkanols A, B, and C, from the flowers of Chrysanthemum indicum L. Chem. Pharm. Bull. 3: 340-345
27 Hisashi, M., Toshio, M., Iwao, T. and Masayuki, Y. (2002) Structural Requirements of Flavonoids and Related Compounds for Aldose Reductase Inhibitory Activity. Chem. Pharm. Bull. 50: 788-795   DOI   ScienceOn
28 Okuda, J., Miwa, I., Inagaki, K., Horie, T. and Nakayama, M. (1982) Inhibition of aldose reductases from rat and bovine lenses by flavonoids. Biochem. Pharmacol. 31: 3807-3822   DOI   ScienceOn
29 Kawanishi, K., Ueda H. and Moriyasu, M. (2003) Aldose Reductase Inhibitors from the Nature. Curr. Med. Chem. 10: 1353-1374   DOI   ScienceOn
30 Handelsman, D. J. and Turtle, J. R. (1981) Clinical trial of an aldose reductase inhibitor in diabetic neuropathy. Diabetes 30: 459-464   DOI
31 Shambhu, D. V. and Jin, H. K. (1976) Inhibition of lens aldose reductase by flavonoids-Their possible role in the prevention of diabetic cataracts. Biochem. Pharmacol. 15: 2505-2513