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Comparison of Nerve Growth Factor Induction by Butanol Fraction of Liriope platyphylla and Ophiopogon japonicus  

Kang, Tong-Ho (Department of Oriental Pharmaceutical Development, Nambu University)
Kim, Sun-Yeou (Graduate School of East-West Medical Science, Kyunghee University)
Publication Information
Korean Journal of Pharmacognosy / v.39, no.2, 2008 , pp. 75-79 More about this Journal
Abstract
Nerve growth factor (NGF) is a protein plays a major role in the development and maintenance of central and peripheral nervous system. Recent data suggest that reduced availability of NGF may play a significant role in the pathogenesis of diabetic $polyneuropathy.^{1)}$ In our previous study, steroidal saponin from Liriope platyphylla showed neurotrophic effect by stimulation of NGF synthesis and activation of tyrosine kinase $signaling.^{2)}$ In this study, we examined the neurotrophic effect of Liriope platyphylla (LP); which was from Mylyang(MYL) and Cheongyang(CHE), and Ophiopogon japonicus (CHI) on in vitro and in vivo model for the comparison of their NGF induction. We quantitatively analyzed spicatoside A in the LP and CHI by HPLC. And we investigated the correlation between the contents of spicatoside A and NGF induction efficacy on PC 12 cells and mouse serum. These results suggest that spicatoside A may enhance NGF induction in animal model.
Keywords
Liriope platyphylla; Ophiopogon japonicus; Nerve growth factor (NGF); mouse; spicatoside A;
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