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Cartilage and Bone Protection Effect of AIF, a water extract from three herbs  

Chang, Sun-Hwa (Research Institute, Oscotec Inc.)
Lee, Byung-Eui (Research Institute, Oscotec Inc.)
Jung, Dong-Sik (Research Institute, Oscotec Inc.)
Han, Jeong-Hyun (Research Institute, Oscotec Inc.)
Park, Jung-Ae (Research Institute, Oscotec Inc.)
Shim, Sung-Bo (Research Institute, Oscotec Inc.)
Kim, Se-Won (Research Institute, Oscotec Inc.)
Kim, Jung-Keun (Research Institute, Oscotec Inc.)
Publication Information
Korean Journal of Pharmacognosy / v.39, no.1, 2008 , pp. 1-6 More about this Journal
Abstract
AIF has been formulated using three herbs known to have anti-inflammatory and anti-osteolytic effects. In this study, the potential therapeutic effects of AIF for osteoarthritis were assessed in vitro and in vivo. The effects of AIF on the cartilage and bone protection (MMP-13 expression, GAG degradation, OPG release) were examined, in vitro. In addition, the therapeutic effect of AIF was evaluated using a chemical-induced osteoarthritis rat model. Rats were injected with iodoacetate intraarticularly in one knee joint and treated with the oral administration of 100 mg/kg AIF-glucosamine once a day for 3 weeks. And then, destruction of cartilage and bone was evaluated by histopathological assessment. AIF significantly inhibited the production of MMP13 and GAG in a dose dependent manner in vitro. Also, AIF increased the production of OPG. In OA rat model, the AIF-glucosamine treated group reduced cartilage destruction, compared to vehicle or glucosamine treated group. AIF showed potent protective effects for the destruction of cartilage and bone, in vitro and in vivo. These results suggest that AIF contains effective compound(s) which may modify the progression of arthritis.
Keywords
AIF; cartilage protection; bone protection;
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1 Goldring, S. R. (2003) Pathogenesis of bone and cartilage destruction in rheumatoid arthritis. Rheumatology (Oxford). 42: 1-16   DOI   ScienceOn
2 Pelletier, J. P., Martel-Pelletier, J. and Raynauld, J. P. (2006) Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow. Arthritis Res Ther. 8: 11-14   DOI   ScienceOn
3 Yoshikawa, M., Morikawa, T., Yashiro, K., Murakami, T. and Matsuda, H. (2001) Bioactive saponins and glycosides. XIX. Notoginseng (3): immunological adjuvant activity of notoginsenosides and related saponins: structures of noto-ginsenosides-L, -M, and -N from the roots of Panax noto-ginseng (Burk.) F. H. Chen. Chem Pharm Bull. 49: 1452-1456   DOI   ScienceOn
4 Yoshikawa, M., Murakami,. T., Veno, T., Yashiro, K., Hirokawa, N., Yamahara, J., Matsuda, H., Saijioh, R. and Tanaka, O. (1997) Bioactive saponins and glycosides. VIII. Notoginseng (1): new dammarane-type triterpene oligogly-cosides, notoginsenosides-A, -B, -C, and -D, from the dried root ofPanax notoginseng (Burk.) F.H. Chen. Chem. Pharm. Bull. 45: 1039-1045   DOI   ScienceOn
5 Kim, D. S., Chang, Y. J., Zedk, U., Zhao, P., Liu, Y. Q., and Yang, C. R. (1995) Dammarane saponins from Panax ginseng. Phytochemistry. 40: 1493-1497   DOI   ScienceOn
6 Zhao, Y., Wen, X. S., Cui, J. and Wu, W. H. (2006) Extraction and salting-out purification of alpha-galactosidase and beta-glucosidase from fresh roots of Rehmannia glutinosa. Zhong. Yao. Cai. 29: 137-139
7 Raju, B. L., Lin, S. J., Hou, W. C., Lai, Z. Y., Liu, P. C. and Hsu, F. L. (2004) Antioxidant iridoid glucosides from Wend-landia formosana, Natural Product Res. 8: 357-364
8 Sridhar, C., Subbaraju, G. V., Venkateswarlu, Y. and Venugopal, R. T. (2004) New acylated iridoid glucosides from Vitex altissima. J. Natural Products. 67: 2012-2016   DOI   ScienceOn
9 Fujikawa, T., Yamaguchi, A., Morita, J., Takeda, H. and Nishibe, S. (1996) Protective effects of Acanthopanax senticosus Harms from Hokkaido and its components on gastric ulcer inrestrained cold water stressed rats. Biol. Pharm. Bull. 19: 1227-1230   DOI   ScienceOn
10 Awang DV. (1996) Siberian ginseng toxicity may be a case of mistaken identity. Can. Med. Assoc. J. 155: 1237-1239
11 Wieland, H. A., Michaelis, M., Kirschbaum, B. J. and Rudolphi, K. A. (2005) Osteoarthritis - an untreatable disease? Nat Rev Drug Discov. 4: 331-344   DOI   ScienceOn
12 Kim, H. A., Cho, M. L., Choi, H. Y., Yoon, C. S., Thun, J. Y., Oh, H. J. and Kim, H. Y. (2006) The catabolic pathway mediated by toll-like receptors in human osteoarthritic chondrocyte. Arthritis Rheum. 54: 2152-2163   DOI   ScienceOn
13 Kim, S. S., Son, Y. O., Chun, J. C., Kim, S. E., Chung, G .H., Hwang, K. J. and Lee, J. C. (2005) Antioxidant property of an active component purified from the leaves ofparaquat-tolerant Rehmannia glutinosa. Redox. Rep. 10: 311-318   DOI   ScienceOn
14 Westhoff, C. S., Freudiger, D., Petrow, P., Seyfert, C., Zacher, J., Kriegsmann, J., Pap, T., Gay, S., Stiehl, P., Gromnica-Ihle, E. and Wernicke, D. (1999) Characterization of collagenase 3 (matrix metalloproteinase 13) messenger RNA expression in the synovial membrane and synovial fibroblasts ofpatients with rheumatoid arthritis. Arthritis Rheum. 42: 1517-1527   DOI   ScienceOn
15 Wang, J. Z., Mao, X. J., Ito, H. and Shimura, K. (1991) Immunomodulatory activity of polysaccharide from Acanthopanax obovatus roots. Planta. Med. 57: 335-336   DOI   ScienceOn
16 Chang, S. H., Sung, H. C., Choi, Y. L., Ko, S. Y., Lee, B. E., Baek, D. H., Kim, S. W. and Kim, J. K. (2005) Suppressive effect of AIF, a water extract from three herbs, on collagen-induced arthritis in mice. Int Immunopharmacol. 5: 1365-1372   DOI   ScienceOn
17 Shen, M. L., Zhai, S. K., Chen, H. L., Luo, Y. D., Tu, G. R. and Ou, D. W. (1991) Immunopharmacological effects of polysaccharides from Acanthopanax senticosus on experimental animals. Int. J. Immunopharmacol. 13: 549-554   DOI   ScienceOn
18 Alarcon, G. S. (2001) Epidmiology of rheumatoid arthritis. Rheum Dis Clin North Am. 27: 269-282   DOI
19 Bone Cho Kang Mook [Compendium of material medical] 1978
20 Theill, L. E., Boyle, W. J. and Penninger, J. M. (2002) RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu. Rev. Immunol. 20: 795-823   DOI   ScienceOn
21 Wang, J. Z., Tsumura, H., Shimura, K. and Ito, H. (1992) Antitumor activity of polysaccharide form a Chinese medicinal herb, Acnthopanax giraldii Harms. Cancer Lett. 65: 79-84   DOI   ScienceOn
22 Takayanagi H. (2007) Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol. 7: 292-304   DOI   ScienceOn
23 Takasugi, N., Moriguchi, T., Fuwa, T., Sanada, S., Ida, Y., Shofi, J. and Saito, H. (1985) Effect of Eleutherococcus senticosus and its rectal temperature, body and grip tones, mortor coordination, and exploratory and spontaneous movements in acute stressed mice. Shoyakugaku Zasshi. 39: 232-237
24 Asagiri, M. and Takayanagi, H. (2007). The molecular understanding of osteoclast differentiation. Bone 40: 251-264   DOI   ScienceOn
25 Walsh, N. C., Crotti, T. N., Goldring, S. R. and Gravallese, E. M. (2005) Rheumatic diseases: the effects of inflammation on bone. Immunol Rev. 208: 228-251   DOI   ScienceOn
26 Janusz, M. J., Hookfin, E. B., Heitmeyer, S. A., Woessner, J. F., Freemont, A. J., Hoyland, J. A., Brown, K. K., Hsieh, L. C., Almstead, N. G., De, B., Natchus, M. G., Pikul, S. and Taiwo, Y. O. (2001) Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors. Osteoarthritis Cartilage. 9: 751-760   DOI   ScienceOn
27 Shan, B. E., Yoshita, Y., Sugiura, T. and Yamashita, U. (1999) Suppressive effect of Chinese medicinal herb, Acanthopanax gracilistylus, extract on human lympocytes in vitro. Clin. Exp. Immunol. 118: 41-48   DOI