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Isolation of Melanin Biosynthesis Inhibitory Compounds from the Roots of Asarum sieboldii  

Choi, Eun-Hyang (College of Pharmacy, Yeungnam University)
Choi, Ji-Young (College of Pharmacy, Yeungnam University)
Lee, Jong-Gu (College of Pharmacy, Yeungnam University)
Oh, Joon-Seok (College of Pharmacy, Yeungnam University)
Kim, Dong-Chun (College of Pharmacy, Yeungnam University)
Lee, Hee-Sang (College of Pharmacy, Yeungnam University)
Son, Jong-Keun (College of Pharmacy, Yeungnam University)
Son, Ae-Ryang (Department of Beauty Design, Geochang Provincial College)
Kim, Jeong-Ah (College of Pharmacy, Yeungnam University)
Lee, Seung-Ho (College of Pharmacy, Yeungnam University)
Publication Information
Korean Journal of Pharmacognosy / v.38, no.4, 2007 , pp. 394-399 More about this Journal
Abstract
Eight compounds were isolated from the roots of Asarum sieboldii and their structures were identified as $({\pm})$-car-3-ene-2,5-dione (1), (-)-asarinin (2), (-)-sesamin (3), eucarvone (4), methyleugenol (5), ${\gamma}-asarone$ (6), pellitorine (7) and asarinol A (8) by analysis of spectral data. Among them, (-)-asarinin (2) showed the most potent inhibitory effect on melanogenesis, with inhibition rate of 66%.
Keywords
Asarum sieboldii; melanogenesis inhibitor; (-)-asarinin; methyleugenol;
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