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Isolation and Development of Quantitative Determination of Torilin from the Torilis Fructus  

Hwang, Eui-Il (Health Food Research Group, KT&G Central Research Institute)
Lee, Seong-Kye (Health Food Research Group, KT&G Central Research Institute)
So, Seung-Ho (Health Food Research Group, KT&G Central Research Institute)
Koo, Bon-Suk (Health Food Research Group, KT&G Central Research Institute)
Han, Gyeong-Ho (Health Food Research Group, KT&G Central Research Institute)
Kim, Na-Mi (Health Food Research Group, KT&G Central Research Institute)
Publication Information
Korean Journal of Pharmacognosy / v.38, no.4, 2007 , pp. 321-326 More about this Journal
Abstract
For the propose of the quality control of Torilis Fructus, one major compound was isolated by several column chromatograpies and identified by its spectral data as torilin (8,11-dihydroxy-8-angeloyl-11-acetyl-4-guaien-3-one). A quantitative analysis of torilin using HPLC method showed that the average contents at 230 and 254 nm were $7.167{\pm}0.168mg/g\;and\;7.052{\pm}0.160mg/g$, respectively, in 18 samples collected throughout the regions of Korea and China. This method provided a tool for standardization of the commercial Torilis Fructus.
Keywords
Torilis Fructus; Quantitative analysis; Torilin; HPLC;
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연도 인용수 순위
1 한 대석, 유시명 (1964) 본초학, 181. 동명사, 서울
2 Youn, H. J., Lakritz, J., Kim, D. Y., Rottinghaus, G. E. and Marsh, A. E. (2003) Anti-protozoal efficacy of medicinal herb extracts against Toxoplasma gondii and Neospora caninum. Veterinary Parasitology. 116: 7-14   DOI   ScienceOn
3 Kim, M. S., Lee, Y. M., Moon, E. J., Kim, S. E., Lee, J. J. and Kim, K. W. (2000) Anti-angiogenic activity of torilin, a sesquiterpene compound isolated from Torilis japonica. Int. J. Cancer. 87: 269-275   DOI   ScienceOn
4 박종희, 성상현 (2007) 핵심약용식물, 193. 신일북스, 서울
5 Park, W. S., Son, E. D., Nam, G. W., Kim, S. H., Noh, M. S., Lee, B. G., Jang, I. S., Kim, S. E., Lee, J. J. and Lee, C. H. (2003) Torilin from Torilis japonica, as a new inhibitor of testosterone 5..-reductase. Planta Medica. 69: 459-461   DOI   ScienceOn
6 Kang, S. S., Lee, E. B., Kim, T. H., Kim, K. R. and Jung, J. H. (1994) The NMR assignments of torilin from Torilis japonica. Arch. Pharm. Res. 17(4): 284-286   DOI
7 Kitajima, J., Suzuki, N. and Tanaka, Y. (1998) Guaiane-type sesquiterpenoid glycosides from Torilis japonica. Chem. Pharm. Bull. 46: 1743-1747   DOI   ScienceOn
8 Lee, E. B., Kim, S. M. and Kim, T. H. (1998) Anti-inflammatory activities of Torilis japonica fruit. Kor. J. Pharmacogn. 29(4): 384-390
9 Chikamatsu, H., Maeda, M. and Nakazaki, M. (1969) Structure of torilin. Tetrahedron. 25(19): 4751-4765   DOI   ScienceOn
10 Oh, H., Kim, J. S., Song, E. K., Cho, H., Kim, D. H., Park, S. E., Lee, H. S. and Kim, Y. C. (2002) Sesquiterpenes with hepatoprotective activity from Cnidium monnieri on tacrineinduced cytotoxicity in Hep G2 cells. Planta Medica. 68: 748-749   DOI   ScienceOn
11 Kitajima, J., Suzuki, N., Ishikawa, T. and Tanaka, Y. (1998) New hemiterpenoid pentol and monoterpenoid glycoside of Torilis japonica fruit, and consideration of the origin of apiose. Chem. Pharm. Bull. 46: 1583-1586   DOI
12 Fujita, S. (1990) Miscellaneouis contributions to the essential oils of plants from various territories. LI. On the components of essential oils of Torilis japonica (Houtt.) DC. Yakugaku Zasshi. 110(10): 771-775   DOI
13 육창수 (1982) 한국약품식물자원도감, 298. 진명출판사, 서울
14 김창민 (2001) 원색한약도감, 144. 아카데미서적, 서울
15 Itokawa, H., Matsumoto, H., Mizuno, K., Watanabe, K., Morita, M. and Iitaka, Y. (1986) Structure of torilolide and oxytorilolide: novel germacranolides from Torilis japonica (Houtt) D.C. Chem. Pharm. Bull. 34: 4682-4686   DOI
16 Lee, E. B., Cho, S. I., Kang, S. S., Kim, K. R. and Kim, T. H. (1999) Isolation of torilin from Torilis japonica fruit and its analgesic and anti-inflammatory activities. Kor. J. Pharmacogn. 30(2): 137-144
17 정보섭, 신민교 (1990) 도해향약(생약)대사전, 416. 영림사, 서울
18 Itokawa, H., Mimashi, S., Watanabe, K., Natsumoto, H. and Hamanaka, T. (1983) Studies on the constituents of crude drugs having inhibitory activity against contraction of the ileum caused by histamine of barium chloride. Shoyakugaku Zasshi. 37: 223-228
19 上海科學技術出版社 小學館編(1985) 中藥大辭典, 第 二卷, 2354. (株)小學館, 東京
20 Lim, H. S., Park, P. U., Kim, K. H. and Park, K. S. (1995) Hemostatic action of Torilis fructus. Yakhak Hoeji. 39(1): 55-60   과학기술학회마을