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Inhibitory Activity of Ethanol Extracts of Ailanthus altissima and Luteolin-7-glucoside on Phospholipase $A_2$ activity  

Kim, Mi-Hwa (College of Pharmacy, Yeungnam University)
Hwang, Nam-Kyong (College of Pharmacy, Yeungnam University)
Hong, Tae-Gyun (College of Pharmacy, Yeungnam University)
Kim, Youn-Kyung (College of Pharmacy, Yeungnam University)
Chung, Hwan-Ki (College of Pharmacy, Yeungnam University)
Yang, Ju-Hae (College of Pharmacy, Yeungnam University)
Jeon, Cheol-Gu (College of Pharmacy, Yeungnam University)
Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
Thanh, Pham Ngoc (College of Pharmacy, Chungnam National University)
Son, Kun-Ho (Department of Food and Nutrition, Andong National University)
Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University)
Kang, Sam-Sik (Natural Products Res. Institute. Seoul National University)
Chang, Hyeun-Wook (College of Pharmacy, Yeungnam University)
Publication Information
Korean Journal of Pharmacognosy / v.38, no.3, 2007 , pp. 277-280 More about this Journal
Abstract
In our continuing effort to investigate compounds having anti-inflammatory activity from natural products, Ailanthus altissima was examined. Among six compounds isolated from Ailanthus altissima, Luteolin-7-O-glucoside (L7G) along with ethanol extract of Ailnathus altissima (EAa) were chosen to determine their inhibitory activity on secretory recombinant phospholipase $A_2s$ enzyme activity in vitro. As a results, EAa inhibited human recombinant $sPLA_2-V$ ($IC_{50}$ of about 100 ${\mu}g/ml$) and $cPLA_2$, ($IC_{50}$ of about 59 ${\mu}g/ml$), while L7G showed strong inhibitory effect on $sPLA_2-A$, V and $cPLA_2$ with an $IC_{50}$ value of approximately 40 ${\mu}M$, respectively.
Keywords
Ailanthus altissima; Luteolin-7-O-glucoside; Phospholipase $A_2$; inflammation;
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