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Cytotoxic constituents from the stem of Rhododendron mucronulatum  

Hong, He-Sun (College of Pharmacy, Kangwon National University)
Jeon, Seung-Ho (College of Pharmacy, Kangwon National University)
Kwon, Yong-Soo (College of Pharmacy, Kangwon National University)
Publication Information
Korean Journal of Pharmacognosy / v.38, no.3, 2007 , pp. 227-233 More about this Journal
Abstract
Seven compounds were isolated from the n-BuOH soluble fraction of stem of Rhododendron mucronulatum as cytotoxic principles against brine shrimp lethality test. On the basis of spectral data, seven compounds were identified as (-)-catechin (1), (+)-epicatechin (2), taxifolin (3), scopoletin (4), quercetin (5), $taxifolin-3-O-{\alpha}-L- arabinopyranoside$ (6), and astragalin (7). Among tested compounds, $taxifolin-3-O-{\alpha}-L-arabinopyranoside$ (6) exhibited potent activity with $LC_{50}$ value at 4.6 ${\mu}g/ml$.
Keywords
Cytotoxiciy; Rhododendron mucronulatum; brine shrimp lethality test; $taxifolin-3-O-{\alpha}-L-arabinopyranoside$;
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Times Cited By KSCI : 3  (Citation Analysis)
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