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Phenolic Constituents from the Flowers of Synurus excelsus  

Lee, Il-Kyun (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University)
Yang, Min-Cheol (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University)
Lee, Kyu-Ha (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University)
Choi, Sang-Un (Korea Research Institute of Chemical Technology)
Lee, Kang-Ro (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University)
Publication Information
Korean Journal of Pharmacognosy / v.38, no.2, 2007 , pp. 181-186 More about this Journal
Abstract
Seven phenolic compounds, scopoletin (1), caffeic acid methyl ester (2), apigenin 7-O-${\alpha}$-L-rhamnosyl-(1${\rightarrow}$6)-O-${\alpha}$-D-glucoside (3), isorhamnetin 7-O-${\alpha}$-D-glucoside (4), isorhamnetin 3-O-${\alpha}$-D-glucoside (5), luteolin (6), and quercetin 3-methyl ether (7) were isolated from the methanol extract of the flowers of S. excelsus. Their structures were established by chemical and spectroscopic methods. The isolated compounds were tested for their cytotoxicity against four human cancer cell lines in vitro using a SRB method. The compounds 4 and 7 showed moderate cytotoxicity with ED$_{50}$ values ranging from 1.59 to 13.14${\mu}$g/ml.
Keywords
Compositae; Synurus excelsus; phenolic constiuents; Cytotoxicity;
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