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Effects of Protein-Bound Polysacharide Isolated from Acanthopananx senticosus in Reducing the Toxic Effects of Cisplatin  

Lee, Keyong-Ho (Kolon Life Science, Inc.)
Yoon, Won-Ho (Department of Science and Technology, Seoil College)
Publication Information
Korean Journal of Pharmacognosy / v.38, no.2, 2007 , pp. 152-156 More about this Journal
Abstract
Protein-bound polysaccharide is derived from Acanthopananx senticosus by the cold water extraction. The aim of the study was to evaluate the effects of PS against weight loss and hematological change as a indication of toxicity produced by the treatment of cisplatin. PS protected the weight loss caused by cisplatin (6 mg/kg) and significantly recovered hematological change. Treatment of PS showed the recovery on the weight loss and hematological change as indicators of toxicity of cisplatin treatment. By increasing lymphocyte proliferation and cytokine production, PS may be highly effective in protecting against cisplatin-induced toxicity. The results suggest PS might have a role in reducing toxicity or permitting larger dose of cisplatin to be given.
Keywords
protein-bound polysaccharide; Acanthopanax senticosus; cisplatin; cytoprotection;
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