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Cancer Chemopreventive Activity of the Rhizome Extract of Alpinia officinarum  

Ku, Kang-Mo (College of Agricultural and Life Science, Kyungpook National University)
Chang, Young-Jin (College of Agricultural and Life Science, Kyungpook National University)
Kim, Min-Gun (College of Agricultural and Life Science, Kyungpook National University)
Kim, Kil-Ung (College of Agricultural and Life Science, Kyungpook National University)
Song, Kyung-Sik (College of Agricultural and Life Science, Kyungpook National University)
Kang, Young-Hwa (College of Agricultural and Life Science, Kyungpook National University)
Publication Information
Korean Journal of Pharmacognosy / v.38, no.1, 2007 , pp. 95-99 More about this Journal
Abstract
In order to find novel cancer chemopreventive agents, quinone reductase (QR) inductive activity of methanol extract of herbal medicines was examined using murine hepatoma, hepa1c1c7 cells. QR has been used as an anticarcinogenic marker enzyme in cancer chemoprevention study. The methanol extract of Alpinia officinarum (Zingiberace) showed showed significantly strong quinone reductase inductive activity compared to the control group. The methanol extract of Alpinia officinarum was successively fractionated with various solvents according to polarity. Hexane, ethyl acetate, buthanol and water fractions were obtained and theirs activities were assessed. The QR inductive effect was moved to the ethyl acetate fraction and was highly increased. The CD (concentration required to double the specific activity of QR) value of ethyl acetate fraction was 8.6 ${\mu}g/mL$. Alpinia officinarum also showed strong antioxidant activity. These results suggest that Alpinia officinarum can be developed as cancer chemopreventive agent.
Keywords
Cancer chemoprevention; Quinone reductase; Antioxidant; Alpinia officinarum;
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