Browse > Article

Effects of Ginseng Radix Plus Crataegi Fructus on the Mice Model of Alzheimer's Disease  

Han, Sin-Hee (Department of Oriental Health Care, Joongbu University)
Kil, Gi-Jung (Department of Oriental Medicine Resources, Joongbu University)
Publication Information
Korean Journal of Pharmacognosy / v.37, no.4, 2006 , pp. 314-319 More about this Journal
Abstract
This research was investigated the effect of the Ginseng Radix plus Crataegi Fructus (Gin-CF) on Alzheimer's disease. Specifically, the effects of the Gin-CF extract on $IL-1\beta,\;TNF-\alpha$ of BV2 microglia cell line treated with LPS. The Gin-CF extract suppressed the over-expression of $IL-1\beta$ protein, $TNF-\alpha$ protein, MDA, and CD68/CD11b, in the mice with Alzheimer's disease induced by ${\beta}A$. These results suggest that the Gin-CF extract may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the Gin-CF extract for Alzheimer's disease is suggested for future research.
Keywords
Ginseng Radix; Crataegi Fructus; Alzheimer's disease;
Citations & Related Records
연도 인용수 순위
  • Reference
1 金知赫, 黃義完 (1992) 東醫精神醫學, 256-271, 327-330, 現代醫學書籍土, 서울
2 Borchelt, D. R., Thinakaren, G, Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C. M., Kim, G, Seekins, S., Yager, D., Slunt, H. H., Wang, R., Younkin, S. G and Sisodia, S. S. (1996) Familial Alzheimer's diease-linked presenilin 1 variants elevate ${\beta}A1-42$/1-40 ratio in vitro and in vivo, Neuron, 17: 1005-1013   DOI   ScienceOn
3 Kowall, N. W., Beal, M. E, Busciglio, J., Duffy, L. K. and Yankner, B. A. (1991) An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P. Proc. Natl. Acad Sci. 88(16): 7247-7251
4 Selkoe, D. J. (1991) Scientific American, November, 68-72. Scientific American Inc. New York
5 Dickson, D. W., Ksiezak-Reding, H., Liu, W. K., Davies, P., Crowe, A. and Yen, S. H. (1992) Immunocytochemistry of neurofibrillary tangles with antibodies to subregions of tau protein ; identification of hidden and cleaved tau epitopes and a new phosphorylation site, Acta Neuropathol, 84(6): 596-605
6 Tabaton, M., Cammarata, S., Mandybur, T, Richey, P., Kawai, M., Perry, G and Gambetti, P. (1992) Senile plaques in cerebral amyloid angiopathy show accumulation of amyloid precursor protein without cytoskeletal abnormalities. Brain Res. 593(2) : 299-303   DOI   ScienceOn
7 Ons, S. K., Kitamura, M., Maekawa, K., Hirata, M., Ano, W., Ukai, T and Yamafuji, Narita H. (1993) Protective effects of R(-)-1-(benzo[b]thiophen-5-yl)2-[2-(N,N-diethy-lamino) ethoxy]-ethanol hydrocholride (T-588), a novel cerebral activator, against experimental cerebral anoxia, Jap. Pharm. 62: 81-86   DOI
8 辛民敎 (1997) 臨床本草學, 585-586, 영림사, 서울
9 Breakfield, X. O. and DeLuca, N. A. (1991) Herpes simplex virus for gene delivery to neurons, New Biol, 3: 203-218
10 Chong, Y H. (1997) Effect of a carboxy-terminal fragment of Alzheimer's amyloid precursor protein on expression of proinflammatory cytokines in rat glial cells, Life Sciences, 61(23) : 2323-2333   DOI   ScienceOn
11 Kandel, E. R., Schwartz, J. H. and Jessell, T. M. (1991) Principles of Neural Science 3rd edition, McGraw-Hill Medical, New York
12 孫星衍 輯 (1979) 神農本草經, 40-41, 문광도서유한공사, 臺北
13 Suematsu, T, Kamada, T, Abe, H., Kikuchi, S. and Yagi, K. (1977) Serum lipoperoxide levels in patients suppering from liver disease. Clin. Chim. Acta 79: 267-770   DOI   ScienceOn
14 이광우, 정희원 (1997) 임상신경학, 199-210, 고려의학, 서울
15 McGeer, E. G and McGeer, P. L. (1998) The importance of inflammatory mechanisms in Alzheimer disease. Exp. Gerontol. 33(5): 371-378   DOI   ScienceOn
16 Altstiel, L. D. and Sperber, K. (1991) Cytokines in Alzheimer's disease, Prog. Neuro. Psychopharmacol. Biol. Psychiat. 15(4): 481-495   DOI   ScienceOn
17 徐舜圭 (1992) 成人病束礪羅샘p, 225-228, 230-232, 고려의학, 서울
18 강서중의학원 (1984) 中藥大辭典, 170-172, 대성출판사, 대구
19 郭隆璨 (1992) 圖解腦神經科學, 27-31, 第一醫學社, 서울
20 Alzheimer's Disease Collaboratory Group (1995) The structure of the presenilin 1(S182) gene and identification of six novel mutations in early onset AD families, Nat. Gene. 11: 35, 219-222   DOI   ScienceOn
21 Weinstein, H. C, Scheltens, P., Hijdra, A. and van Royen, E. A. (1993) Neuroimaging in the diagnosis of Alzheimer's disease II. Positron and single photon emission tomography. Clinical Neuro. Neurosurg. 95(2): 81-91   DOI   ScienceOn
22 Lemere, C. A., Lopera, E, Kosik, K. S., Lendon, C. L., Ossa, J., Saido, T. C, Yamaguchi, H., Ruiz, A., Maritnez, A., Madrigal, L., Hincapie, L., Arango, J. C, Anthony, D. C, Koo, E. H., Goate, A. M., Selkoe, D. J. and Arango, J. C. (1996) The E280A presenilin 1 Alzheimer mutation produces increased ${\beta}A$ 42 deposition and severe cerebellar pathology, Nat. Med. 2(10): 1146-1150   DOI   ScienceOn
23 李時珍 (1987) 本草鋼目, 1013-1014, 고문사, 서울