Browse > Article

Screening of Natural Resources with Inhibitory Activity on Free Radicals and Advanced Glycation end Products (AGEs) Formation  

Kim, Min-Suk (Department of Medicinal Plant Resources, Mokpo National University)
Kim, Dong-Wook (Department of Medicinal Plant Resources, Mokpo National University)
Rhyu, Dong-Young (Department of Medicinal Plant Resources, Mokpo National University)
Publication Information
Korean Journal of Pharmacognosy / v.37, no.4, 2006 , pp. 307-313 More about this Journal
Abstract
Reactive oxygen species (ROS) and formation of advanced glycation end products (AGEs) play an important role in the pathogenesis of diabetic nephropathy by hyperglycemia. To find natural agents improving diabetic nephropathy, 63 natural resources which used to the treatment of diabetes mellitus in a folk remedy were investigated with an in vitro system employing radical scavenging activity and inhibitory activity of AGEs formation. In results, the extracts of Aspalathus linearis, Rubus coreanus, Rosa rugosa, and Epimedium koreanum significantly inhibited the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical with $IC_{50}$ values less than $10{\mu}g/ml$. The extracts of Zea mays, Cucurbita moschata, Cudrania tricuspidata, and Aspalathus linearis effectively reduced the formation of AGEs compared with the positive control $N-acetyl-_L-cystenine$ (NAC) and aminoguanidine (AG). In addition, the extracts of Aspalathus linearis, Commelina communis, Cornus officinalis, and Lespodeza cuneata showed the all inhibitory activity against DPPH radical and AGEs formation. Also, these resources definitely showed the radical scavenging activity against peroxynitrite $(ONOO^-)$ and hydroxyl radical $({\cdot}OH)$ relating to high glucose-induced ROS production. Thus, these results suggest that some natural resources may regulate the initiation and progression of diabetic nephropathy through inhibition of ROS production and AGEs formation.
Keywords
diabetic nephropathy; reactive oxygen species (ROS); advanced glycation end products (AGEs); natural resources;
Citations & Related Records
연도 인용수 순위
  • Reference
1 이희발 (2001) 당뇨병과 말기신부전증에서의 후기당화산물의 생산과 그 역할. 대한신장학회지 20(1): 1-3
2 Yokozawa, T., Nakagawa, T. and Terasawa, K. (2001) Effects of oriental medicines on the production of advanced glycation endproducts. Journal of Traditional Medicines 18: 107-112
3 Lee, H. B, Cha, M. K, Song, K. I, Kim, J. H, Lee, E. Y, Kim, S. I., Kim, J. and Yoo, M. H. (1997) Pathogenic role of advanced glycosylation end products in diabetic nephropathy. Kidney Int. Suppl. 60: S60-S65
4 Lee, H. B., Ha, H. and King, G L. (2003) Reactive oxygen species and diabetic nephropathy. J. Am. Soc. Nephrol. 14: S209-S210   DOI
5 Beckman, J. S. and Koppenol, W. H. (1996) Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am. J. Physiol. 271(5): C1424-C1437
6 Shin, J. S., Kim, K. S., Joeng, G H., Cheong, C. S., Ko, K. H., Park, H. I., Huh, H. and Kim, B. K. (1997) Antidiabetic Activity of Lycii Fructus. Kor. J. Pharmacogn. 28(3): 138-142   과학기술학회마을
7 Maeda, H. and Akaike, T. (1998) Nitric oxide and oxygen radicals in infection, inflammation, and cancer. Biochemistry 63(7): 854-865
8 김혜순, 이인규 (2002) 최종당화산물에 의한 혈관평활근세포 증식. 대한당뇨병학회 26(2): 87-90
9 Ha, H. C, Kim, H. S. and Ryu, B. H. (2000) Antioxidative effects of ethanol extract obtained from Rooibos Tea(Aspalathus linearis) and It's application of food. Korean J. Food & Nutr. 13(1): 13-20
10 이동진, 이지영 (2004) 작물의 유용성분 분석 및 평가. 한국작물학회. 187-194
11 Lee, H. J, An, J. U, Lee, B. J., Mun, S. G and Seo, Y W. (2004) Antioxidant activity of Rosa rugosa. Korea J. Biotechnol. Bioeng. 19(1): 67-71
12 Gross, J. L., de Azevedo, M. J., Silveiro, S. P., Canani, L. H., Caramori, M. L. and Zelmanovitz, T. (2005) Diabetic nephropathy: diagnosis, prevention, and treatment. Diabetes Care. 228(1): 164-176
13 Ha, H. and Lee, H. B. (2003) Reactive oxygen species and matrix remodeling in diabetic kidney. J. Am. Soc. Nephrol. 14: S246-S249   DOI
14 한상국, 강준원 (2002) 고급산화법에서 생성되는 free radical의 전자기공명법에 의한 정성분석. J of KSEE. 24(7): 1153-1161
15 하헌주, 김경환 (1997) 당뇨병성 선증의 발생과 진행에 관여하는 산화성 스트레스의 역할. 대한신장학회지 16(2): S134-S139
16 Kooy, N. W., Royall, J. A., Ischiropoulos, H. and Beckman, J. S. (1994) Peroxynitrite-mediated oxidation of dihydrorhodamine 123. Free Radic. Biol. Med. 16(2): 149-156   DOI   ScienceOn
17 Park, W Y, Ro, J. S. and Lee, K. S. (2001) Hypoglycemic effect of Cudrania tricuspidata Root Bark. Kor. J. Pharmacogn. 32(3): 248-252   과학기술학회마을
18 Makita, Z, Radoff, S, Rayfield, E. J, Yang, Z., Skolnik, E., Delaney, V., Friedman, E. A., Cerami, A. and Vlassara, H. (1991) Advanced glycosylation end products in patients with diabetic nephropathy. N. Engl. J. Med. 325(12): 836-842   DOI   ScienceOn
19 Cooper, M. E. (1998) Pathogenesis, prevention, and treatment of diabetic nephropathy. Lancet. 352(9123): 213-219   DOI   ScienceOn
20 Thuraisingham, R. C, Nott, C. A., Dodd, S. M. and Yaqoob, M. M. (2000) Increased nitrotyrosine staining in kidneys from patients with diabetic nephropathy. Kidney Int. 57(5): 1968-1972   DOI   ScienceOn
21 Ulicna, O., Vancova, O., Bozek, P., Carsky, J., Sebekova, K., Boor, P., Nakano, M. and Greksak, M. (2006) Rooibos tea (Aspalathus linearis) partially prevents oxidative stress in streptozotocin-induced diabetic rats. Physiol. Res. 55(2): 157-164
22 Rahbar, S. and Figarola, J. L. (2003) Novel inhibitors of advanced glycation endproducts. Arch. Biochem. Biophys. 419(1): 63-79   DOI   ScienceOn
23 대한신장학회 등록위원회 (1999) 우리나라 신대체 요법 현황. 대한신장학회지 4: S343-S354
24 Lee, H. B., Ha, H., Kim, S. I. and Ziyadeh, F. N. (2000) Diabetic kidney disease research: Where do we stand at the turn of the century? Kidney Int. 58(Suppl. 77): S1-S2
25 Kamat, J. P. (2006) Peroxynitrite: a potent oxidizing and nitrating agent. Indian J. Exp. Biol. 44(6): 436-447
26 Ceriello, A. (2003) New insights on oxidative stress and diabetic complications may lead to a 'causal' antioxidant therapy. Diabetes Care. 26(5): 1589-1596   DOI   ScienceOn
27 Renal data system, USRDS (1999) Annual data report, National institute of diabetes and digestive and kidney disease
28 Xu, H. Q. and Hao, H. P. (2004) Effects of iridoid total glycoside from Cornus officinalis on prevention of glomerular overexpression of transforming growth factor beta 1 and matrixes in an experimental diabetes model. Biol. Pharm. Bull. 27(7): 1014-1018   DOI   ScienceOn
29 Lee, J. W, Do, J. H. and Lee, S. K. (2000) Antioxidant Activity of the aerial part of Epimedium koreanum $N_{AKAI}$. J. Korean Soc. Food Sci. Nutr. 29(4): 732-736   과학기술학회마을
30 Sato, T., Iwaki, M., Shimogaito, N., Wu, X., Yamagishi, S. and Takeuchi, M. (2006) TAGE (toxic AGEs) theory in diabetic complications. Curr. Mol. Med. 6(3):351-358   DOI   ScienceOn
31 Yoon, I., Cho, J. Y, Kuk, J. H., Wee, J. H., Jang, M. Y, Ahn, T. H. and Park, K. H. (2002) Indentification and activity of antioxidative compounds from Rubus coreanum fruit. Food Sci. Technol. 34(5): 898-904