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Anti-inflammatory and Immunomodulatory Effects of the Botanical Product $AMP-365^{TM}$  

Shin, Eun-Myoung (National Products Research Institute, College of Pharmacy, Seoul National University)
Kim, Dong-Hyun (College of Pharmacy Kyung Hee University)
Kwon, Young-Bok (Atomaru Co., Gapyeong-gun)
Kim, Yeong-Shik (National Products Research Institute, College of Pharmacy, Seoul National University)
Publication Information
Korean Journal of Pharmacognosy / v.37, no.3, 2006 , pp. 212-216 More about this Journal
Abstract
The effect of aqueous extracts of medicinal plants $AMP-365^{TM}$ was tested for immune system regulating activity based on anti-inflammatory activity, anti-oxidant, macrophage proliferation and T-lymphocyte proliferation activity. $AMP-365^{TM}$ dose-dependently increased proliferation of RAW264.7 macrophage cells and its nitric oxide production as well as DPPH radical scavenging activity. On the other hand, T-lymphocyte proliferation activity was decreased on dose-dependent manner. Passive cutaneous anaphylaxis reaction was alleviated by 49% by administering 250 mg/kg of $AMP-365^{TM}$. The results suggest that $AMP-365^{TM}$ can be beneficial in the treatment of immediate allergic reactions as an adjuvant supplement material.
Keywords
atopic dermatitis; anti-inflammatory effect; antioxidant; herbal extract;
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