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Antihypertensive Effect of Ecklonia cava Extract  

Hong, Jang-Hee (College of Medicine, Konyang University)
Son, Bum-Soo (College of Medicine, Konyang University)
Kim, Bum-Kyeong (College of Medicine, Konyang University)
Chee, Hee-Youn (College of Medicine, Konyang University)
Song, Kyung-Sik (Division of Applied Biology and Chemistry, College of Agriculture and Life Sciences, Kyungpook National University)
Lee, Bong-Ho (Department of Biotechnology, Hanbat National University)
Shin, Hyen-Cheol (Livechem Co., Ltd.)
Lee, Kyung-Bok (College of Medicine, Konyang University)
Publication Information
Korean Journal of Pharmacognosy / v.37, no.3, 2006 , pp. 200-205 More about this Journal
Abstract
Ecklonia cava is brown alga which ow in the sea all over the world. It has been shown that Ecklonia cava has antioxidative, anticoagulant, and antiviral effect, lately. In this study, we examined the antihypertensiye effect of Ecklonia cava extract (Eca) on 2-kidney 1-clip Goldblatt Hypertensive Rats (GB-HT). In vitro assay, the angiotensin converting enzyme (ACE) activity was significantly inhibited by Eca (27-95% inhibition at $10-50\;{\mu}g/ml$). The systolic blood pressure of Eca-treated GH-HT significantly was decreased compared to that of control CB-HT (15% decrease at 50 mg/kg). The serum ACE activity was also inhibited 19% with 50 mg/kg Eca treatment. These results suggest that Eca can be used as antihypertensive functional foods and nutraceuticals.
Keywords
Ecklonia cava; angiotensin-converting enzyme; antihypertensive;
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Times Cited By KSCI : 2  (Citation Analysis)
Times Cited By SCOPUS : 3
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