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Hypolipidemic and Antioxidative Effects of Bangpoongtongsungsankamibang on Diet-Induced Obesity Rats  

Jeong, Seoung-Hee (College of Pharmacy, Kyunghee University)
Lee, Kyung-Tae (College of Pharmacy, Kyunghee University)
Ann, Hong-Sik (College of Oriental Medicine, Kyunghee University)
Lee, Jin-Yong (College of Oriental Medicine, Kyunghee University)
Choi, Jong-Won (College of Pharmacy, Kyungsung University)
Kim, Deog-Gon (College of Oriental Medicine, Kyunghee University)
Publication Information
Korean Journal of Pharmacognosy / v.37, no.3, 2006 , pp. 190-195 More about this Journal
Abstract
Obesity is associated with a number of pathological disorders such as non-insulin-dependent diabetes, hypertension, hyperlipidemia, and cardiovascular diseases. Bangpoongtongsungsankamibang (BTSK) has been widely used in the oriental medicine for the treatment of several diseases associated with inflammatory abnormalities in cardiovascular and nervous system. The BTSK is the modified prescription of Bangpoongtongsungsankamibang in which sea tangle (Laminaria japonica) were added. This study was carried out to detemine the anti-obestic effects of BTSK. Pretreatment with the BTSK at daily dose of 100 or 200 mg/kg (p.o.) far 4 weeks reduced serum triglyceride, total cholesterol contents in rat induced by Poloxamer-407 or Triton WR-1339, respectively. Furthermore, post-treatment with BTSK far four weeks also inhibited body weight gain, adipose tissue mass and hyperlipidemia induced by the high fat diet for six weeks. The BTSK shifted serum total-, HDL- and LDL-cholesterol levels toward the values of normal group, suggesting that BTSK has hypolipldemlc effects. The rats fed BTSK reduced lipid peroxide and hydroxy radical in the rat blood and increased superoxide dismutase (SOD) activity compared to the control group. Taken together, these results superoxide that BTSK improve hyperlidemia and obesity via the upregulation of anti-oxidative mechanism.
Keywords
Hyperlipidemia; Obesity; Bangpoongtongsungsankamibang; Anti-oxidative activity; Cholesterol;
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1 Kim, M.S., Chung, H.S., Lee, J.G., Lim, W.K., Hwang, C.Y., Lee, E.J., Cho, K.H., Wi, D.H., and Kim, H.M. (2002) Inhibition of cytokine production by the traditional oriental medicine, 'Gamcho-Sasim-Tang' inmitogen-stimulated peripheral blood mononuclear cells from Adamantiades-Behcet's patients. J. Ethnopharmacol. 83: 123-12S   DOI   ScienceOn
2 정성현, 임동술, 이숙연 (2004) 가미청간탕이 rat의 알콜성 지방간에 미치는 영향. 생약학회지, 35 : 229-232
3 Kim, K.H., Kim, Y.W., Kim, H.B., Lee, B.J., and Lee, D.S. (2006) Anti-apoptotic activity of laminarin polysaccharides and their enzymatically hydrolyzed oligosaccharides from Laminaria japonica, Biotechnology Letters 28: 439-446   DOI
4 오민석, 이우열, 윤일지 (2005) 방풍통성산(防風通聖散)에 대한 문헌적 고찰, 대전대학교 한의학연구소 논문집, 14 : 155-165
5 이남훈, 신길선, 조기호, 김영석, 배형섭, 이경섭 (1991) 방풍통성산이 고혈압 고지혈에 미치는 영향, 경희의학, 7: 101-9
6 안정미, 김성수, 신현대 (1993) 방풍통성산이 비만유도백서의 체중 및 지질대사에 미치는 영향, 경희의학. 9: 69-82
7 성현제 (1984) 방풍통성산의 진통 소염 해열 및 항균 작용에 관한 실험적 연구, 경희대학교 대학원
8 Kusama, H., Nishiyama, M., and Ikeda, S. (1988) Pharmacological investigation of bezafibrate, a hypolipidemic agent (1). Effects of bezafibrate on normal and experimental hyperlipidemia in rats. Nippon Yakurigaku Zasshi. 92: 175180   DOI   ScienceOn
9 Yagi, K. (1987) Lipid peroxides and human disease. Chemistry and Physics of Lipids. 45: 337   DOI   ScienceOn
10 Wout, Z.G., Pee, E.A., Maggiore, J.A., Wiliams, R.H., Palichara, P., and Johnston, T.P. (1992) Poloxamer 407-mediated changes in plasma cholesterol and triglycerides following intraperitoneal injection to rats. Parenter Sci. Technol. 46: 192-200
11 Yamamoto, I., Maruyama, H., and Moriguchi, M. (1987) The effect ofdietary seaweeds on 7,12-dimethyl-benz[a]anthracene induced mammary tumorigenesis in rats. Cancer Lett. 35: 109-118   DOI   ScienceOn
12 Oyanagui, Y. (1984) Reevaluation of assay methods and establishment of Kit for superoxide dismutase activity. Anal Biochem. 42: 290
13 Hayashi, H., Shitara, M., and Yamasaki, F. (1982) The origin of lipid accumulated in the liver lysosomes after administration of triton WR-1339. J. Biochem. 92: 1585-1590   DOI
14 Colliec, S., Fischer, A.M., Tapon-Bretaudiere, J., Boisson, C., Durand, P., and Jozefonvicz, J. (1991) Anticoagulant properties of a fucoidan fraction. Thromb Res. 15: 143-154
15 Kobatake, Y, Saito, M., Kuroda, K., Kobayashi, S., Innami, S. (1987) Influence of fish consumption on serum lipid and lipid peroxide concentrations in middle aged subjects. J Japan Soc Nutr & Food Sci. 40: 103   DOI
16 윤성찬, 안성훈, 문연자, 김진경 (2003) 혈관신생 및 이식 암세포증식 억제를 통한 가미소암산의 항암작용연구, 동의생리병리학회지, 17, 969-979
17 Valko, M., Rhodes, C.J., Moncol, J., Izakovic, M., Mazur, M. (2006) Free radicals, metals and antioxidants in oxidative stress-induced cancer. 10: 1-40   DOI   ScienceOn
18 맹정균 (1985) 방풍통성산이 $CCI_{4}$ 중독백서의 혈액상에 미치는 영향, 경희대학교 대학원
19 Lee, J.W., Jhee, O., Yuan, H., Kim, T., Kim, D., Lee, M., Om, A., Lee, B., Park, S.K., and Kang, J. (2005) Effect of korean oriental medicine extract on bone mass as compared with alendronate in ovariectomized Rats. J. Med. Food. 8: 369-376   DOI   ScienceOn