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Inhibitory Activity on Monoamine Oxidase of Prunella vulgaris  

Hwang, Keum-Hee (Bio-Food and Drug Research Center, Konkuk University)
Publication Information
Korean Journal of Pharmacognosy / v.37, no.3, 2006 , pp. 157-161 More about this Journal
Abstract
We examined the inhibitory activities against monoamine oxidase (MAO) of Prunella vulgaris in vitro and in vivo methods. Methanolic extract of P. vulgaris showed significantly Inhibitorγ activities on MAO-A and MAO-B that were prepared from rat brain and liver in vitro. The inhibitory activities were measured by serotonin and benzylamine as substrates, respectively. MAO-A and MAO-B activities were potently inhibited by ethylacetate extracts of P. vulgaris in vitro tests. It was observed that those activities in vivo tests have different tendency each other. MAO-A activity was increased by the oral administration of methanolic extract of P. vulgaris while MAO-B activity was decreased. Consequently, we suggest that P. vulgaris may have the effects on the inhibitory activities against MAO both in vitro and in vivo.
Keywords
monoamine oxidase (MAO); serotonin (5-HT); Prunella vulgaris;
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