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Oxidative Characteristics of Norditerpene Alkaloids  

Song, In-Sung (College of Pharmacy, Kyungsung University)
Kim, Hye-Kyung (College of Pharmacy, Kyungsung University)
Heo, Kyong-Hee (College of Pharmacy, Kyungsung University)
Lee, Chung-Kyu (College of Pharmacy, Kyungsung University)
Publication Information
Korean Journal of Pharmacognosy / v.37, no.1, 2006 , pp. 60-66 More about this Journal
Abstract
Norditerpene alkaloids are the main toxic principles of traditional oriental herb 'chuawu(bu-shi),' which have been used in Chinese materia medica mainly for the treatment of musculoskeletal disorders. They are biosynthesized via cyclization of geranylgeranyl pyrophosphate, incoration of 2-aminoethanol and decarboxylation not via amino acid pathway, and the structural characteristics have tempted several oxidative reactions. In this study various norditerpene alkaloids were subjected to react active manganese dioxide and oxoammonium salt as oxidants. The oxidation was proceeded as dealkylation with aconitine type and dehydrogenations with lycoctonin and heteratisine type.
Keywords
norditerpene alkaloid; aconitine type alkaloid; oxidation; active $MnO_2$; oxoammonium salt;
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