Browse > Article

Vasorelaxation Effect of the Flavonoids from the Rhizome Extract of Alpinia offcinarum on Isolated Rat Thoracic Aorta  

Kim, Hye-Jin (Korea Research Institute of Chemical Technology)
Yoo, Mi-Young (Korea Research Institute of Chemical Technology)
Kim, Hyun-Ki (Korea Research Institute of Chemical Technology)
Lee, Byung-Ho (Korea Research Institute of Chemical Technology)
Oh, Kwang-Suk (Korea Research Institute of Chemical Technology)
Seo, Ho-Won (Korea Research Institute of Chemical Technology)
Yon, Gyu-Hwan (Korea Research Institute of Chemical Technology)
Gendaram, Odontuya (Institute of Chemistry and Chemical Technology, Mongolian Academy of Sciences)
Kwon, Dae-Young (Korea Food Research Institute)
Kim, Young-Sup (Korea Research Institute of Chemical Technology)
Ryu, Shi-Yong (Korea Research Institute of Chemical Technology)
Publication Information
Korean Journal of Pharmacognosy / v.37, no.1, 2006 , pp. 56-59 More about this Journal
Abstract
The vascular relaxant effets of Alpinia officinarum(Zingiberaceae) were evaluated on isolated thoracic aorta from rats. The methanolic extract of rhizome of Alpinia officinarum caused a concentration-dependent relaxation of rat aortic preparations precontracted with $0.3{\mu}M$ phenylephrine, The intensive investigation of the extract by way of activity-guided fractionation led us to yield three kind of active components, galangin(1), kaempferide(2), and kaempferol(3), which were responsible for the vasodilating property of the extract. Stuctures of the isolated active components were established by chemical and spectroscopic means.
Keywords
Alpinia officinarum; Zingiberaceae; vascular relaxant; flavonoid;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Shin. J.E., Han, M.J. and Kim, D.H. (2003) 3-Methylether galagin isolated from Alpinia officinarum inhibits pancreatic lipase. BioI. Pharm. Bull. 26: 854-857   DOI   ScienceOn
2 Park, H.J., Lee, J.H., Kim, S.Y, Shim, B.S., Ku, H.J., Kang, J.M., Choe, J.D., Kim, N.J., Lee, J.S. and Lim, S. (2005) Anti-inflammatory effect of Alpiniae officinari rhizoma extract. Kor. J. Herbology. 20: 43-53
3 Curir, P, Dolci, M., Lazotti, V. and Taglialatela-Scafati, O. (2001) Kaempferide triglycoside: a possible factor of resistance of carnation (Dianthus caryophyllus) to Fusarium oxysporum f. sp. dianthi. Phytochemistry. 56: 717-721   DOI   ScienceOn
4 No, M.S., Ha, J.Y, Lee, C.H., Lee, Y.Y, Lee, S.H. and Lee, J. J. (1998) Inhibitory activities of natural products on lipopolysaccaride induced prostaglandin production in mouse macrophages. Yakhak Hoeji. 42: 558-566
5 Kiuchi, F., Iwakami, S., Shibuya, M., Hanaoka, E and Sankawa, U. (1992) Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diaryIheptanoids. Chem. Pharm. Bull. 40: 387-391   DOI   ScienceOn
6 Yang, Y, Kinoshida, K., Koyama, K., Takahashi, K., Tai, T., Nunoura, Y and Watanada, K. (1999) Antiemetic principles of Alpinia katsumadai Hayata. Nat. Prod. Sci. 5: 20-24
7 Choi, J.S., Woo, W.S., Young, H.S. and Park, J.H. (1990) Phytochemical study on Prunus davidiana. Arch. Pharm. Res. 13: 374-378   DOI
8 소학관편, (1985) 중약대사전 제2권, 782, 상해과학기술출판사
9 Kim, J.H., Lee, S.E., Hwang, H.J., Ha, J.S. and Jeong, H.S. (2003) Screening of medicinal plant extracts for antioxidant activity. Life Science 73: 167-179   DOI   ScienceOn
10 Li, B.H. and Tian, W.X. (2003) Presence of fatty acid synthase inhibitors in the rhizome ofAlpinia officinarum Hance. J. Enzyme Inhib. Med. Chem. 18: 349-356   DOI   ScienceOn
11 Kuroyanagi, M., Noro, T., Fukushima, S., Aiyama, R., Itokawa, H. and Morita, M. (1983) Studies on the constituents of the seeds of Alpinia katsumadai Hayata. Chem.Pharm. Bull. 31: 1544-1550   DOI
12 Burges, R.A., Gardiner, D.G, Gwilt, M., Higgins, A.J., Blackburn, K.J., Campbell, S.F, Cross, P.E. and Stubbs, J.K. (1987) Calcium channel blocking properties of amlodipine in vascular smooth muscle and cardiac muscle in vitro: evidence for voltage modulation of vascular dihydropyridine receptors. J. Cardiovasc Pharmacal. 9: 110-119
13 Kang, S.S., Kim, JS., Son, K.H., Kim, H.P. and Chang, H.W. (2000) Isolation of COX-2 inhibitors from Alpinia officinarum. Kor. J Pharmacogn. 31: 57-62   과학기술학회마을
14 Lee, S.C., Shin, K.S. and Heo, M.Y (2002) Protection of ROS-induced cytotoxicity and DNA damage by the extract of Alpinia officinarum. J. Fd Hyg. Safety. 17: 106-116
15 Bleier, W. and Chirikdjian, J.J. (1972) Uber die Flavonoide von Rhizoma Galange (Alpinia officinantm Hance). Planta Med. 22: 145-151   DOI
16 한의과대학 본초학 편찬위원회 (2004) 본초학, 388-389. 영림사
17 Morello, S., Vellecco, V, Alfieri, A., Mascolo, N. and Cicala, C. (2006) Vasorelaxant effect of the flavonoid galangin on isolated rat thoracic aorta. Life Science 78: 825-830   DOI   ScienceOn