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Hepatoprotective Effects of Aqueous Extract from Aerial Part of Agrimmony  

Kang, Se-Chan (College of Pharmacy, SungKyunKwan University)
Lee, Chang-Min (College of Pharmacy, SungKyunKwan University)
Koo, Hyun-Jung (College of Pharmacy, SungKyunKwan University)
Ahn, Dong-Ho (BIOKOREA Co., LTD.)
Choi, Han (College of Pharmacy, SungKyunKwan University)
Lee, Jae-Hyun (College of Pharmacy, SungKyunKwan University)
Bak, Jong-Phil (College of Pharmacy, SungKyunKwan University)
Lee, Mi-Hyun (College of Pharmacy, SungKyunKwan University)
Choung, Eui-Su (College of Pharmacy, SungKyunKwan University)
Kawk, Jong-Hwan (College of Pharmacy, SungKyunKwan University)
Lee, Min-Kyung (BIOKOREA Co., LTD.)
Oh, Joa-Sub (College of Pharmacy, SungKyunKwan University)
Zee, Ok-Pyo (College of Pharmacy, SungKyunKwan University)
Publication Information
Korean Journal of Pharmacognosy / v.37, no.1, 2006 , pp. 28-32 More about this Journal
Abstract
Hepatoprotective effects of an aqueous extract prepared from the aerial part of Agrimonia eupatoria L., a species of agrimmony, were investigated in experimental liver-damaged models. To investigate hepatoprotective effects, the agrimmony extract were fed orally to experimental animals. Thereafter a single dose of hepatotoxin, carbon tetrachloride $(CCl_4)$ or D-galac-tosamine was orally administrated. Chronic liver damage was induced by oral administration of $CCl_4$ for 2 weeks (1 time/day). Hepatoprotective effects were monitored by estimating serum AST and ALT levels. The results showed that the agrimmony extract significantly reduced AST and ALT levels compared with those of control group in both acute and chronic animal models. It was concluded that the agrimmony extract have hepatoprotective effects against rat liver injury induced by $CCl_4$ or D-galactosamine.
Keywords
Agrimmony extract; Agrimonia eupatoria L.; acute/chronic liver damage; carbon tetrachloride; D-galactosamine;
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