Browse > Article

Biological Activities of Sarcodon aspratus (Berk.) S. Ito  

Woo, Eun-Rhan (College of Pharmacy, Chosun University)
Park, Young-Jun (College of Pharmacy, Chosun University)
Moon, Young-Hee (College of Pharmacy, Chosun University)
Publication Information
Korean Journal of Pharmacognosy / v.36, no.4, 2005 , pp. 305-310 More about this Journal
Abstract
Sarcodon aspratus (Thelepholaceae), a native mushroom, is distributed in Korea and Japan, and has been widely used in traditional food and fork medicines. To confirm the biological activities of Sarcodon aspratus, the liver protecting activity, anti-clotting activity, and anti-complementary activity of the water extract, EtOH extract, and the water soluble proteoglycan part of S. aspratus were investigated. The EtOH, and water extract of S. aspratus decreased the GOT and GPT releases induced by $CCl_4$ in a dose-dependant manner. On the other hand, the water soluble proteoglycan part of S. aspratus showed weak inhibitory activity. In addition, the EtOH and water extract of S. aspratus prevented $CCl_4-induced$ hepatotoxicity, as described by a liver histopathologic study. To confirm the anti-clotting activity, the APTT and PT assay were carried out. As a result, only the crude proteoglycan part of S. aspratus showed the anti-coagulating activity, and this result might be due to the inhibition of intrinsic clotting system. Also, the crude proteoglycan part of S. aspratus showed the anti-complementary activity, and the $IC_{50}$ value was $50\;{\mu}l/ml$.
Keywords
Sarcodon aspratus; hepatoprotective effect; anti-coagulating activity; anti-complementary activity;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Thompson, A. R. and Horker, L. A. (1983) Manual ofhemostasis and thrombosis. Davis, F. A. 178-185, Philadelphia
2 Kobayash, T. (1960) Fatty liver by hepatotoxic agents and lipid metabolism in rats(2). Yakugaku Zasshi 80: 1612-1624   DOI
3 Tasuziro, I. (1978) Morphology and classification, in the Biology an Cultivation of Ebile Mushroom, 3-35, Academic press, New York
4 Meda, S., Suda, K., Miyamoto, Y, Takeda, S., Shinbo, M., Aburada, M., and Ikeya, Y (1982) Effects ofShizandra fruits on drugs induced hepatic damage in rats. Yakugaku Zasshi 102: 579-588   DOI
5 Klerx, J. P, Beukelman, H. V., Dijk, J. M., and Willers, M. N. (1983) Microassay for colorimetric estimation of complement activity in guinea pig, human and mouse seIUm. J. Immunol. Methods 63: 215-220   DOI   ScienceOn
6 Groot, H. and Noll, T. (1986) The crucial role of oxygen partial pressures in haloalkane free radical mediated lipid peroxidation. Biochem. Pharamcol. 35: 15-20   DOI   ScienceOn
7 Yamasaki, Y and Suzuki, Y (1978) Purification and properties of $\beta$-glucosidase and glucamylase from Lentinus edodes (Berk.) Sing. Agri. Biol. Chem. 42: 971-976   DOI
8 Maruyama, H., Yamazaki, K, Murofushi, S., Konda, C. and Ikekawa, T. (1989) Antitumor Activity of Sarcodon a.lpratus (Berk.) S. Ito and Ganoderma lucidurn (Fr.) Karst. J. Pharmacobio-pym. 12: 118-123   DOI
9 Oh, S. R., lung, K. Y, and Lee, H. K. (1996) MiCro-screening Method for Natural Resources. Agri. Chem. Biotech. 39: 147-152
10 Holts, R. B. (1972) Qualitative and quantitative analysis of free neutral carbohydrate in mushroom tissue by gas-liquid chromatography and mass spectrometry. J. Agr. Food Chem. 19: 1272-1278   DOI
11 장재철(1989) 능이(能栮) Proteolytic enzyme 이 폐계(廢鷄)에 미치는 軟肉效果.群山大學 自然科學硏究 6: 159-168
12 Park, W. H. (1986) Studies on Enzymes ofthe Higher Fungi of Korea (1), Identification of protease in Sarcodon aspratus. Kor. J. Mycol. 14: 25-30
13 Berger, L. M., Bhatt, H. H., Combes, B., and Estabrook, R. W. (1986) $CCI_{4}$-induced toxicity in isolated hepatocytes: The impotence of direct of solvent injury. Hepatol. 6: 36-42   DOI   PUBMED
14 Uhm, T. B., Ryu, K. S., Kim, M. K., and You, J. S. (1991) Characterization of a Serine Protease from Neungee [Sarcodon aspratus(Berk.)S. Ito]. J. Kor. Soc. Food Nutr. 120: 35-39
15 Vogel, F. S., McGarry, S. J., Kemyer, L. A. K., and Graham, D. G (1974) Bacteriological properties of a class of quinoid compound related to sporulation in the mushroom Agaricus bisporus. Am. J. Pathol. 76: 165-171
16 Ikekawa, T., Uehara, N., Maeda, Y, Nakamishi, M., and Fukouka, F. (1969) Antitumor activity of aqueous extract of some edible mushroom. Cancer Res. 29: 734-741
17 Mizuno, T., Oshsawa., K., Hagiwara, N., and Kuboyama, R. (1982) Studies on the host-mediated antitumor polysaccharide part VI, fractionation. chemical structure, chemical modification and antitumor activity of homo and heteroglucans isolated from Mitake. the fruiting body of Grifola frondosa. Bull. Fac. Arg. 35: 49-55
18 Lee, T. K (1986) Purification and some Chracteristics of the proteolytic enzyme in fruitbody of Neungee (Sarcodon aspratus (Berk). S. Ito.). J. Kor. Soc. Food Nutr. 17: 276-282
19 Lee, T. K., Eun, J. S., Yang, J. H., Jo, D. Y, and Yang, H. C. (1989) Studies on Higher Fungi in Korea (Ill), Purification and Stability of proteolytic Enzyme Sarcodon aspratus (Berk.) S. Ito. J. Kor. Pharm. Sci. 19: 81-86
20 Lee, T. K, Eun, J. S., Yang, J. H., Jo, D. Y, and Yang, H. C. (1989) Studies on Higher Fungi in Korea (III), Purification and Stability of proteolytic Enzyme Sarcodon aspratus (Berk.) S. Ito. J. Kor. Pharm. Sci. 19: 81-86
21 Swada, J. (1964) Studies on the acid-protease of Paecilomyces varioti Bainer TPR-220. Part II, Some enzymatic properties of the crystalline acid-protease. Arg. Biol. Chem. 28: 348-354   DOI
22 Kaarcholm, N. C. and Schack, P. (1983) Characterization of papaya peptidase a as an enzyme of extreme basicity. Acta Chem. Scand(B). 37: 607-703
23 Eun, J. S., Yang, J. H., Che, D. Y, Lee, T. K, and Park, I. H. (1989) Studies on Higher Fungi in Korea (II), proteolytic Enzyme ofAgaricus bisporus Sing. J. Kor. Pham. Sci. 19: 914
24 Moon, Y H., Woo, E. R., and Park, Y J. (2002) Antitumor Activity of a Water Soluble Proteoglycan Isolated from Sarcodon aspratus(Berk.) S. Ito. Kor: J. Pharmacogn. 33: 224 - 229
25 Kim, D. H., Bae, E. A., Jang, I. S., and Han, M. J. (1996) Anti-Helicobacter pylori Activity of Mushrooms. Arch.Pharm. Sci. 19: 447-449
26 Park, W. H. (1983) Studies on Components of Sarcodon a.lpratus( II ). Kor. J Mycol. 11: 159-162
27 Park, W. H. (1983) Studies on Components of Sarcodon aspratus(I). Kor. J. Mycol. 11: 85-89
28 Albino, E., Carinr, R., Parola, M., Bellomo, G, Goria-Gatti, L. G, and Dianzani, M. U. (1989) Effects of carbon tetrachloride on calcium homeostasis, a critical reconsideration. Biochem. Pharmacol. 38: 2719-2724   DOI   ScienceOn
29 Richard, O. R., Eric, A. G, and Robert, S. B. (1991) Free radical damage and lipid peroxidation. Hepatoxicology, 40: CRC Press, Florida
30 Eun, J. S., Yang, J. H., Cho, D. Y, and Lee, K T. (1988) Studies on Higher Fungi in Korea (1), Activity of proteolytic Ezyme from Sarcodon aspratus (Berk.) S. Ito. J. Kor. Pharm. Sci. 19: 125-131
31 Mitchell, J. R., Hughes, H., Lauterburg, B. H., and Smith, C. V. (1982) Chemical nature ofreactive intermediates as determinant of toxicologic responses. Drug Metabol. Rev. 13: 539-550   DOI   ScienceOn