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Evaluation of the Antinociceptive Properties of GCSB-5, a Herbal Formulation  

Lee, Chan-Ho (College of Pharmacy, Sungkyunkwan University)
Kim, Sung-Hwa (College of Pharmacy, Sungkyunkwan University)
Lee, Jun-Seok (College of Pharmacy, Sungkyunkwan University)
Cho, Kang-Hoon (College of Pharmacy, Sungkyunkwan University)
Kim, Jeoung-Seob (Biosapogen Co., Ltd.)
Cho, Soon-Hyun (Hanpoong Pharmaceutical Co., Ltd.)
Lee, Sun-Mee (College of Pharmacy, Sungkyunkwan University)
Publication Information
Korean Journal of Pharmacognosy / v.36, no.4, 2005 , pp. 299-304 More about this Journal
Abstract
This study examined the antinociceptive properties of GCSB-5, a herbal formulation consisting of 6 Oriental herbs (Ledebouriellae Radix, Achyranthis Radix, Acanthopanacis Cortex, Cibotii Rhizoma, Glycine Semen, and Eucommiae Cortex) that are used in traditional medicine to treat various bone disorders, mainly of which involve analgesic processes. Peripheral and central analgesic models were established in experimental animals in order to evaluate the antinociceptive effects of the agent. GCSB-5 significantly inhibited the number of acetic-induced writhing (33.3%-34.3% inhibition at 100-600 mg/kg) but increased the pain threshold (38.0% increase at 300 mg/kg) in the Randall-Selitto test. However, GCSB-5 had no effect on the hot plate-induced nociception and hyperalgesia from the tail-pinch method. These results suggest that the antinociceptive effect of GCSB-5 may be mediated via peripheral mechanisms.
Keywords
antinociceptive; arthritis; GCSB-5; peripheral analgesic activity;
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1 Corley, D. A., Kerlikowske, K., Verma, R. and Buffier, P, (2003) Protective association of aspirin/NSAIDs and esophageal cancer: a systematic review and meta-analysis. Gastroenterology 124: 47-56   DOI   ScienceOn
2 Kim, H. W., Kwon, Y. B., Ham, T. W Roh, D. H., Yoon, S. Y, Han, H. J., Kang, S. K., Lee, H. J., Mar, W. C., Yang, I. S Beitz, A J. and Lee, J. H. (2002) The antinociceptive and anti-inflammatory effect of ethylacetate extracts from Bang Poong (Radix Ledebouriellae) on the Freund's adjuvantinduced arthritis in rats. J Vet. Sci. 3: 343-349
3 Woolfe, G. and MacDonald, A. D. (1944) The evaluation of the analgesic action ofpethidine hydrochloride (DEMEROL). J. Pharmacol. Exp. Ther. 80: 300-307
4 Rittner, H. L., Machelska, H. and Stein, C, (2005) Leukocytes in the regulation of pain and analgesia. J. Leukoc. BioI. 78: 1215-1222   DOI   ScienceOn
5 Collier, H. O. and Schneider, C. (1972) Nociceptive response to prostaglandins and analgesic actions of aspirin and morphine. Nat. New BioI. 236: 141-143   DOI   ScienceOn
6 김창민, 신민교, 안덕균, 이경순 외 (1999) 中藥大辭典, 5147. 도서출판정담. 서울
7 Ghelardini, C., Galeotti, N., Calvani, M., Mosconi, L., Nicolai, R. and Bartolini, A (2002) Acetyl-L-camitine induces muscarinic antinociception in mice and rats. Neuropharmacology 43: 1180-1187   DOI   ScienceOn
8 Randall, L. O. and Selitto, J. J. (1957) A method for measurement of analgesic activity on inflamed tissue. Arch. Int. Pharmacodyn. Ther. 111: 409-419
9 Gordon, G. V., Villanueva, T, Schumacher, H. R. and Gohel, V. (1984) Autopsy study correlating degree of osteoarthritis, synovitis and evidence of articular calcification. J. Rheumatol 11: 681-686
10 Hong, N, D., Rho, Y S., Kim, J. W, Won, D. H., Kim, N. J. and Cho, B. S. (1988) Studies on the general pharmacological activities of Eucommia ulmoides Oliver. Kor. J. Pharmacogn. 19: 102-110
11 Bulka, A, Wiesenfeld-Hallin, Z. and Xu, X. J. (2002) Differential antinociception by morphine and methadone in two sub-strains of Sprague-Dawley rats and its potentiation by dextromethorphan. Brain Res. 942: 95-100   DOI   PUBMED   ScienceOn
12 Saito, H. and Nomura, Y. (1989) Screening methods for drug evaluation. Hirokawa Publishing Company, Tokyo
13 Merskey, H. and Bogduk, N. (1994) Pain terminology. In classification of chronic pain. IASP task force on taxonomy, 209-214. IASP Press. Seattle, WA
14 김창민, 신민교, 안덕균, 이경순 외 (1999) 中藥大辭典, 3019. 도서출판정담. 서울
15 Pascucci, R. A (2002) Use of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 (COX-2) inhibitors: indications and complications, J. Am. Osteopath. Assoc. 102: 487-489
16 Sykes, M. and Nikolic, B. (2005) Treatment of severe autoimmune disease by stem-cell transplantation. Nature 435: 620-627   DOI   ScienceOn
17 Ida, Y, Satoh, Y, Katsumata, M., Nagasao, M Hirai, Y, Kajimoto, T., Katada, N., Yasuda, M, and Yamamoto, T (1998) Two novel oleanolic acid saponins having a sialyl Lewis X mimetic structure from Achyranthes fauriei root. Bioorg. Med. Chem. Lett. 8: 2555-2558   DOI   ScienceOn
18 김창민, 신민교, 안덕균, 이경순 외 (1999) 中藥大辭典, 477. 도서출판정담. 서울
19 Koster, R, Anderson, M. and de Beer, E. J. (1959) Acetic acid for analgesic screening. Fed. Proc. 18: 412-418
20 Rittner, H. L. and Stein, C. (2005) Involvement of cytokines, chemokines and adhesion molecules in opioid analgesia. Eur. J. Pain 9: 109-112   DOI   ScienceOn
21 Tatsumi, S., Mabuchi, T., Katano, T., Matsumura, S., Abe, T, Hidaka, H., Suzuki, M., Sasaki, Y, Minami, T. and Ito, S. (2005) Involvement of Rho-kinase in inflammatory and neuropathic pain through phosphorylation of myristoylated alanine- rich C-kinase substrate (MARCKS). Neuroscience 131: 491-498   DOI   ScienceOn
22 Sandrini, M., Vitale, G and Pini, L. A (2002) Central antinociceptive activity of acetylsalicylic acid is modulated by brain serotonin receptor subtypes. Pharmacology 65: 193-197   DOI   ScienceOn