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Effect of Cumambrin A on the Relaxation of Rat Aorta  

Hong, Yong-Geun (Department of Biochemistry, Division of Life Science, College of Natural Sciences,Graduate School of Applied Life Science, Gyeongsang National University)
Yang, Min-Suk (Department of Agricultural Chemistry, Gyeongsang National University)
Pak, Yun-Bae (Department of Biochemistry, Division of Life Science, College of Natural Sciences,Graduate School of Applied Life Science, Gyeongsang National University)
Publication Information
Korean Journal of Pharmacognosy / v.36, no.1, 2005 , pp. 17-20 More about this Journal
Abstract
We previously reported that the exogenous administration of cumambrin A, a sesquiterpene lactone from the dried flowers of Chrysanthemum boreale Makino has a pharmacological effect on normalization of blood pressure in the spontaneously hypertensive rats (SHR). In the present study, we further investigated the effect of cumambrin A on the relaxation of phenylephrine-induced precontracted rat aortic artery rings. The potency of cumambrin A was than compared to verapamil, a well known $Ca^{2+}-channel$ blocker. The results demonstrate that the isolated rat aortic arteries are relaxed to basal tension at a concentration of $5{\times}10^{-5}\;M$ cumambrin A treatment. The results also show that the phenylephrine-induced contraction is inhibited by a pretreatment of cumambrin A. Co-treatment of cumambrin A and verapamil showed a strong synergetic effect on the relaxation of rat aortic artery rings. Thus, these data demonstrate that cumambrin A is a potent relaxant of rat aortic smooth muscle and suggest that cumambrin A modulates intracellular or extracellular $Ca^{2+}$ mobilization.
Keywords
Cumambrin A; sesquiterpene lactone; high blood pressure; smooth muscle relaxation;
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