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Isolation of Melanogenesis Inhibitors from Ponciri Fructus  

Son, Ae-Ryang (College of Pharmacy, Yeungnam University)
Choi, Ji-Young (College of Pharmacy, Yeungnam University)
Kim, Jeong-Ah (College of Pharmacy, Yeungnam University)
Cho, Se-Hoon (College of Pharmacy, Yeungnam University)
Xu, Guang-Hua (College of Pharmacy, Yeungnam University)
Park, Sung-Hee (College of Pharmacy, Yeungnam University)
Chung, See-Ryun (College of Pharmacy, Yeungnam University)
Chung, Tae-Chun (College of Pharmacy, Yeungnam University)
Jahng, Yurng-Dong (College of Pharmacy, Yeungnam University)
Son, Jong-Keun (College of Pharmacy, Yeungnam University)
Lee, Seung-Ho (College of Pharmacy, Yeungnam University)
Publication Information
Korean Journal of Pharmacognosy / v.36, no.1, 2005 , pp. 1-8 More about this Journal
Abstract
To develop an whitening cosmetics, we isolated the melanogenesis inhibitors from the unripe fruits of Poncirus trifoliata (Rutaceae). Isolated compounds were identified as poncirin(l), naringin(2), bis(2-methylheptyl)phthalate(3), avenalumic acid methyl ester(4) by comparison of physical and spectral data with those reported in the literature. Among the isolated compounds, bis(2-methylheptyl)phthalate showed most potent inhibitory effect on the melanogenesis in cultured B-16 mouse melanoma cell lines$(IC_{50},\;36.8\;{\mu}M)$ compared with kojic acid$(IC_{50},\;150\;{\mu}M)$.
Keywords
Poncirus trifoliata; Rutaceae; bis(2-methylheptyl)phthalate; whitening cosmetics; melanogenesis inhibitors;
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