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Antioxidant Effects and Inhibitory Effect on NO Synthesis by Extracts of Canavalia lineata  

Bu, Hee-Jung (Department of Chemistry, Cheju National University)
Lee, Hye-Ja (Department of pharmacology, College of Medicine, Cheju National University)
Yoo, Eun-Sook (Department of pharmacology, College of Medicine, Cheju National University)
Jung, Duk-Sang (Department of Chemistry, Cheju National University)
Riu, Key-Zung (Division of Horticultural Life Science, Cheju National University)
Lee, Sun-Joo (Department of Chemistry, Cheju National University)
Publication Information
Korean Journal of Pharmacognosy / v.35, no.4, 2004 , pp. 338-345 More about this Journal
Abstract
Scavenging effects of DPPH radical and hydroxyl radical, inhibition of linoleic acid oxidation, inhibition of NO synthesis and iNOS expression were tested with extracts and chromatographic subfractions of Canavalia lineata obtained at Jeju island. Chloroform extract and its subfractions gave moderate effects on scavenging DPPH radical and hydroxyl radical, They also inhibited linoleic acid oxidation, and NO synthesis. Inhibition of NO synthesis resulted from the repression of iNOS gene expression. Ethyl acetate extract and its subfractions showed excellent effects on scavenging DPPH radical and hydroxyl radical, while they were cytotoxic.
Keywords
Canavalia lineata (THUNB.) DC.; DPPH; hydroxyl radical; linoleic acid oxidation; NO assay; iNOS;
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