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Effect of Cnidii Rhizoma on Proliferation of Breast Cancer Cell, Nitric Oxide Production and Ornithine Decarboxylase Activity  

Nam, Kyung-Soo (Intractable Diseases Research Center and Department of Pharmacology, College of Medicine, Dongguk University)
Son, Ok-Lye (Intractable Diseases Research Center and Department of Pharmacology, College of Medicine, Dongguk University)
Lee, Kyung-Hwa (Intractable Diseases Research Center and Department of Pharmacology, College of Medicine, Dongguk University)
Cho, Hyun-Jung (Intractable Diseases Research Center and Department of Pharmacology, College of Medicine, Dongguk University)
Shon, Yun-Hee (Intractable Diseases Research Center and Department of Pharmacology, College of Medicine, Dongguk University)
Publication Information
Korean Journal of Pharmacognosy / v.35, no.4, 2004 , pp. 283-287 More about this Journal
Abstract
The effect of water extract from Cnidii Rhizoma (CRW) on proliferation of human breast cancer cells, nitric oxide production, nitric oxide synthase expression, and ornithine decarboxylase activity was tested. CRW inhibited the growth of both estrogen-dependent MCF-7 and estrogen-independent MDA-MB-23I human breast cancer cells. Lipopolysaccharide-induced nitric oxide (NO) production was significantly reduced by CRW at the concentration of 0.5, 1.0 and 5.0 mg/ml. Expression of inducible nitric oxide synthase (iNOS) was also suppressed with the treatment of CRW in Raw 264.7 cells. CRW inhibited induction of ornithine decarboxylase by 12-0-tetradecanoylphorbol-13-acetate, a key enzyme of polyamine biosynthesis, which is enhanced in tumour promotion. Therefore, CRW is worth further investigation with respect to breast cancer chemoprevention or therapy.
Keywords
Cnidii Rhizoma; nitric oxide; nitric oxide synthase; ornithine decarboxylase; breast cancer chemoprevention;
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